The role of insulin resistance in the development of muscle wasting during cancer cachexia

MA Honors, KP Kinzig - Journal of cachexia, sarcopenia and muscle, 2012 - Springer
… from cancer cachexia tend to exhibit insulin resistance and … in insulin resistance have the
potential to improve cachexia … that insulin resistance may occur prior to the onset of cachexia

Evidence for the contribution of insulin resistance to the development of cachexia in tumor‐bearing mice

ML Asp, M Tian, AA Wendel… - … journal of cancer, 2010 - Wiley Online Library
… , insulin resistance is an early event in mice with cachexia induced … insulin sensitivity and
decreases early markers of cachexia. … that insulin resistance is not only present in cachexia, but …

[HTML][HTML] Insulin resistance and body composition in cancer patients

R Dev, E Bruera, S Dalal - Annals of Oncology, 2018 - Elsevier
… Testosterone replacement in hypogonadic men with cancer cachexia may improve insulin
resistance and has the potential to increase muscle mass but clinical trials are needed. …

Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

GT Ruan, L Deng, HL Xie, JY Shi, XY Liu, X Zheng… - Cancer & …, 2024 - Springer
… , and inflammation and insulin resistance are related to the survival and treatment of cancer
cachexia, this study is based on the previously established inflammation and insulin related …

Insulin treatment in cancer cachexia: effects on survival, metabolism, and physical functioning

K Lundholm, U Korner, L Gunnebo, P Sixt-Ammilon… - Clinical Cancer …, 2007 - AACR
… Most hormones are involved, but insulin resistance appeared early as a presumable
abnormality contributing to weight loss (2), although changes in the noradrenergic system (3), …

Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance

P Arner, D Langin - Trends in Endocrinology & Metabolism, 2014 - cell.com
… disease states such as cancer cachexia and obesity-induced insulin resistance. We highlight
… fat cells and the role of lipolysis in cancer cachexia and obesity-induced insulin resistance. …

Altered glucose metabolism and insulin resistance in cancer-induced cachexia: a sweet poison

T Masi, BM Patel - Pharmacological Reports, 2021 - Springer
… glucose metabolism and insulin resistance and its contribution … to develop new
pharmacological treatment in cancer cachexia. … of insulin resistance in correlation with cancer

Normal protein anabolic response to hyperaminoacidemia in insulin-resistant patients with lung cancer cachexia

A Winter, J MacAdams, S Chevalier - Clinical nutrition, 2012 - Elsevier
Insulin resistance of protein anabolism has been speculated to underlie the skeletal muscle
… of cancer cachexia. We tested whether insulin resistance is present in cachectic lung cancer

Cancer cachexia

MJ Tisdale - Current opinion in gastroenterology, 2010 - journals.lww.com
Cachexia is defined as loss of muscle, with or without fat, frequently associated with anorexia,
inflammation and insulin resistance. Loss of adipose mass is due to an increased lipolysis …

Understanding cachexia as a cancer metabolism syndrome

PE Porporato - Oncogenesis, 2016 - nature.com
… Although insulin resistance is a strong risk factor for cancer development, … insulin resistance
by itself. Indeed, it has been shown that several cancer patients present insulin resistance