… by the fatty acid composition of the diet. However, the molecular basis for insulin resistance
… inputs mediated by fatty acids, which affect the extent of insulin resistance in various organs. …

… fat infusion. We conclude that elevations of plasma FFAs caused insulin resistance and hence
may play a significant role in the pathogenesis of insulin resistance in obesity and NIDDM. …

Evidence is reviewed that free fatty acids (FFAs) are one important link between obesity and
insulin resistance and NIDDM. First, plasma FFA levels are elevated in most obese subjects. …

… Objective: Although elevated free fatty acid (FFA) levels in obesity have been considered to
be of importance for insulin resistance, a recent meta-analysis suggested normal FFA levels …

… suppressed by insulin, itself becomes insulin resistant—thus, … Here we review the background
to the idea of “fatty acids as … show another side to the fatty acids/insulin resistance story. …

… fatty acid–induced insulin resistance as proposed by Randle et al. (2, 27, 28) in which free
fatty acids … in plasma free fatty acid concentration causes insulin resistance by inhibition of …

… it may be the types of dietary fats, or the interaction of fat or fatty acids with other dietary
components that may be a major culprit in the current epidemic of obesity and insulin resistance. …

… trans fatty acid intake with other fatty acids on insulin resistance in … diabetes, trans fatty acid
intake may impair insulin action. In … [42•] demonstrated that trans fatty acids potentiate insulin …

… atherosclerotic process observed in clinical states of insulin resistance [9, 10]. The purpose
of … in relation to insulin sensitivity with emphasis on the role of fatty acids on insulin action and …

… with cardiovascular disease (insulin resistance syndrome), even in the … of insulin resistance
are multifactorial and are only partly understood, but increased availability of free fatty acids (…