… lipid stores could play an unique role in the pathogenesis of skeletal muscle insulin resistance.
The … might shed new light on the pathogenesis of insulin resistance and type 2 diabetes. …

… The association between lipids and insulin resistance is widely accepted. Early studies by
Randle and … Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. …

… Consistent with an indirect effect, we found that a similar lipid infusion protocol in rats resulted
in a reduction of insulin-stimulated IRS-1 tyrosine phosphorylation, which was associated …

… These findings raise the possibility that select lipid predictors not only convey very subtle
metabolic disturbances but could also play a causal role in disease pathogenesis. …

… Free fatty acids are also implicated in inflammation and insulin resistance, as described later
in … Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1 …

… a lipid infusion to induce acute muscle insulin resistance and assessed lipid and inflammatory
parameters that have been previously implicated in causing muscle insulin resistance. We …

… of insulin action and separate chapters cover insulin action in relation to glucose, lipid and
… Section 2 explores the pathophysiological mechanisms of insulin resistance, with discussion …

… muscle insulin resistance was accumulation of storage lipid, consistent with the accepted
glucose/lipid in… structural lipid, and that, in turn, may influence insulin action. Indeed, improved …

… insulin resistance is the etiologic factor responsible for the development of each of the individual
cardiometabolic disturbances… high-dose insulin therapy would increase myocardial lipid …

… ), white adipocytes with multiloculated lipid droplets, and insulin-resistant diabetes was
found to be homozygous for a premature truncation mutation in the lipid droplet protein, CIDEC (…