Muscle mitochondria and insulin resistance: a human perspective

J Hoeks, P Schrauwen - Trends in Endocrinology & Metabolism, 2012 - cell.com
insulin-resistant state instead of being a causal factor. Nonetheless, diminished mitochondrial
function, even secondary to insulin resistanceDeficiency of subsarcolemmal mitochondria

[HTML][HTML] Mitochondrial dysfunction and insulin resistance: an update

MK Montgomery, N Turner - Endocrine connections, 2015 - ec.bioscientifica.com
Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR); …
patients of their insulin treatment and showed that insulin deficiency decreased muscle …

[HTML][HTML] Mitochondrial efficiency and insulin resistance

R Crescenzo, F Bianco, A Mazzoli, A Giacco… - Frontiers in …, 2015 - frontiersin.org
… A possible link between insulin resistance and impaired mitochondrial performance. … of
mitochondrial dysfunction in insulin resistant states have focused the attention on mitochondrial

[HTML][HTML] Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

DJ Fazakerley, R Chaudhuri, P Yang, GJ Maghzal… - Elife, 2018 - elifesciences.org
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic …
Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

CR Hancock, DH Han, M Chen… - Proceedings of the …, 2008 - National Acad Sciences
… that insulin resistance is mediated by a deficiency of muscle … content is mediated by insulin
resistance. Although our … that exercise deficiency is the cause of the mitochondrial deficiency. …

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

J Szendroedi, E Phielix, M Roden - Nature Reviews Endocrinology, 2012 - nature.com
mitochondrial content and improve insulin resistance in some (pre)diabetic cases. Various
mitochondrial … are not necessarily responsible for all forms of insulin resistance. Nevertheless, …

[HTML][HTML] Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance

DH Han, CR Hancock, SR Jung, K Higashida, SH Kim… - PloS one, 2011 - journals.plos.org
… results in decreases of the iron containing mitochondrialInsulin resistance was induced
by feeding iron-deficient and control rats a high fat diet. Skeletal muscle insulin resistance was …

Androgen deficiency and mitochondrial dysfunction: implications for fatigue, muscle dysfunction, insulin resistance, diabetes, and cardiovascular disease

AM Traish, B Abdallah, G Yu - Hormone molecular biology and …, 2011 - degruyter.com
mitochondrial numbers, activation of respiratory chain components, and increased transcription
of mitochondrial-… Androgen deficiency is associated with increased insulin resistance, …

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

K Morino, KF Petersen, GI Shulman - Diabetes, 2006 - Am Diabetes Assoc
insulin resistance in skeletal muscle, we examined insulin-stimulated muscle glucose uptake
in young lean nonsmoking insulin-resistant … diabetes and that insulin resistance is the best …

Mitochondrial dysfunction, insulin resistance, and potential genetic implications: potential role of alterations in mitochondrial function in the pathogenesis of insulin …

P Sangwung, KF Petersen, GI Shulman… - …, 2020 - academic.oup.com
… While the full cellular mechanisms by which SLC16A11 deficiency leads to impaired
mitochondrial function and metabolic processes remain unknown, the authors suggest that the …