Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation
DJ Fazakerley, AY Minard, JR Krycer… - Journal of Biological …, 2018 - ASBMB
… We conclude that elevated mitochondrial oxidants rapidly impair insulin-regulated GLUT4 …
insulin resistance and that MitoPQ is an ideal tool for studying the link between mitochondrial …
insulin resistance and that MitoPQ is an ideal tool for studying the link between mitochondrial …
[PDF][PDF] Liver mitochondria and insulin resistance
G Vial, H Dubouchaud, X Leverve - Acta Biochimica Polonica, 2010 - bibliotekanauki.pl
… -fat diet during 8 weeks and presenting insulin-resistant state, we found impairments of
mitochondrial respiration in intact liver cells as well as in isolated mitochondria (Vial et al., 2010). …
mitochondrial respiration in intact liver cells as well as in isolated mitochondria (Vial et al., 2010). …
Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans?
JF Dumas, G Simard, M Flamment, PH Ducluzeau… - Diabetes & …, 2009 - Elsevier
… of insulin resistance. The aim … mitochondrial dysfunction and insulin resistance in humans.
At present, there are too few studies to definitively conclude that, in this context, mitochondria …
At present, there are too few studies to definitively conclude that, in this context, mitochondria …
Altered mitochondrial metabolism in the insulin‐resistant heart
M Makrecka‐Kuka, E Liepinsh, AJ Murray… - Acta …, 2020 - Wiley Online Library
… to insulin resistance and altered mitochondrial function … levels to induce insulin resistance
and alter mitochondrial function. It … In mice, eNOS deficiency results in a metabolic syndrome-…
and alter mitochondrial function. It … In mice, eNOS deficiency results in a metabolic syndrome-…
Mitochondrial function and dysfunction in exercise and insulin resistance
GP Holloway - Applied physiology, nutrition, and metabolism, 2009 - cdnsciencepub.com
… into mitochondria. The majority of the research on mitochondrial oxidation with insulin
resistance has focused on unraveling the presence and significance of mitochondrial dysfunction. …
resistance has focused on unraveling the presence and significance of mitochondrial dysfunction. …
Etiology of insulin resistance
KF Petersen, GI Shulman - The American journal of medicine, 2006 - Elsevier
… , hypertriglyceridemia, fatty infiltration of the liver and other tissues, and a deficiency of …
-associated decline in mitochondrial function contributes to insulin resistance in the elderly …
-associated decline in mitochondrial function contributes to insulin resistance in the elderly …
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
AJ Sanyal, C Campbell–Sargent, F Mirshahi, WB Rizzo… - Gastroenterology, 2001 - Elsevier
… fatty liver also have higher serum insulin levels than normal individuals.… insulin resistance.16,
19 However, the nature of the metabolic derangements and the sites of insulin resistance …
19 However, the nature of the metabolic derangements and the sites of insulin resistance …
Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance
A Zorzano, M Liesa, M Palacín - Archives of physiology and …, 2009 - Taylor & Francis
… Based on these data, we propose that Mfn2 activity is deficient in skeletal muscle under
insulin resistant conditions such as obesity or type 2 diabetes, and it is likely that this explains …
insulin resistant conditions such as obesity or type 2 diabetes, and it is likely that this explains …
Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans
KH Fisher-Wellman, TM Weber, BL Cathey… - Diabetes, 2014 - Am Diabetes Assoc
… upregulation in mitochondrial capacity … insulin resistance (23–25). Finally, regarding the
third criterion, administration of an iron-deficient diet in rodents failed to induce insulin resistance …
third criterion, administration of an iron-deficient diet in rodents failed to induce insulin resistance …
Mitochondria‐based model for fetal origin of adult disease and insulin resistance
… This model accommodates three critical elements newly identified: first, taurine is an
important structural component of mitochondrial tRNA, and its deficiency during early life causes …
important structural component of mitochondrial tRNA, and its deficiency during early life causes …