Liver adapts mitochondrial function to insulin resistant and diabetic states in mice
A Franko, JC von Kleist-Retzow, S Neschen, M Wu… - Journal of …, 2014 - Elsevier
… -receptor knockout mice impairs RC function, while obesity-induced insulin resistance in
leptin deficient ob/ob or in HFD mice has no effect [8]. Here, we have used the same cohorts of …
leptin deficient ob/ob or in HFD mice has no effect [8]. Here, we have used the same cohorts of …
Mitochondrial Metabolism and Insulin Action
N Turner - Type 2 Diabetes, 2013 - books.google.com
… Interestingly, in the studies reporting mitochondrial deficiencies, there has been disparate
… evidence of a link between mitochondrial dysfunction and insulin resistance is the fact that …
… evidence of a link between mitochondrial dysfunction and insulin resistance is the fact that …
Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: Distinct or interrelated roles?
J Rieusset - Diabetes & metabolism, 2015 - Elsevier
… of mitochondria and ER independently in the development of peripheral insulin resistance,
as … β-oxidation by long-chain acyl-CoA dehydrogenase deficiency causes hepatic steatosis …
as … β-oxidation by long-chain acyl-CoA dehydrogenase deficiency causes hepatic steatosis …
Insulin resistance and mitochondrial abnormalities in NASH: a cool look into a burning issue
P Angulo, KD Lindor - Gastroenterology, 2001 - Elsevier
… derived from the genetically leptin-deficient ob/ob obese mouse that does not develop hepatic
fibrosis, even when exposed to a methionine-choline–deficient diet. This raises the issue …
fibrosis, even when exposed to a methionine-choline–deficient diet. This raises the issue …
5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice
S Saitoh, S Okano, H Nohara, H Nakano… - PLoS …, 2018 - journals.plos.org
… was sufficient to remedy mitochondrial function. Studies on … effect and that ALA deficiency
ultimately leads to heme depletion. … proof that ALA deficiency attenuates mitochondrial function, …
ultimately leads to heme depletion. … proof that ALA deficiency attenuates mitochondrial function, …
[PDF][PDF] Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect
… insulin resistance. Here, we sought to test our hypothesis that a primary defect in mitochondrial
b-oxidation disrupts hepatic insulin … Similar to our findings, deficiency in longchain acyl-…
b-oxidation disrupts hepatic insulin … Similar to our findings, deficiency in longchain acyl-…
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance
… We find that reduction of TFAM in adipose tissue increases mitochondria oxidation
capacity due to complex I deficiency and greater uncoupling. The resultant F-TFKO mice are …
capacity due to complex I deficiency and greater uncoupling. The resultant F-TFKO mice are …
Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance
JA Ibdah, P Perlegas, Y Zhao, J Angdisen, H Borgerink… - Gastroenterology, 2005 - Elsevier
… deficiency … , insulin resistance, and development of NAFLD in mice. Methods: We evaluated
liver histopathology, serum alanine aminotransferase (ALT), glucose, fatty acids, and insulin …
liver histopathology, serum alanine aminotransferase (ALT), glucose, fatty acids, and insulin …
Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance
PA Kakimoto, B Chausse, CC Caldeira da Silva… - PloS one, 2019 - journals.plos.org
… insulin resistance development under all conditions. In parallel with systemic insulin resistance,
we uncovered that hepatic mitochondrial … the observation of mitochondrial dysfunction by …
we uncovered that hepatic mitochondrial … the observation of mitochondrial dysfunction by …
Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells
… Recently, we demonstrated that a deficiency of Cisd2, an iron… the bioenergetic function of
mitochondria and the function of … aimed at preventing and treating insulin resistance and T2D. …
mitochondria and the function of … aimed at preventing and treating insulin resistance and T2D. …