… -receptor knockout mice impairs RC function, while obesity-induced insulin resistance in
leptin deficient ob/ob or in HFD mice has no effect [8]. Here, we have used the same cohorts of …

… Interestingly, in the studies reporting mitochondrial deficiencies, there has been disparate
… evidence of a link between mitochondrial dysfunction and insulin resistance is the fact that …

… of mitochondria and ER independently in the development of peripheral insulin resistance,
as … β-oxidation by long-chain acyl-CoA dehydrogenase deficiency causes hepatic steatosis …

… derived from the genetically leptin-deficient ob/ob obese mouse that does not develop hepatic
fibrosis, even when exposed to a methionine-choline–deficient diet. This raises the issue …

… was sufficient to remedy mitochondrial function. Studies on … effect and that ALA deficiency
ultimately leads to heme depletion. … proof that ALA deficiency attenuates mitochondrial function, …

… insulin resistance. Here, we sought to test our hypothesis that a primary defect in mitochondrial
b-oxidation disrupts hepatic insulin … Similar to our findings, deficiency in longchain acyl-…

… We find that reduction of TFAM in adipose tissue increases mitochondria oxidation
capacity due to complex I deficiency and greater uncoupling. The resultant F-TFKO mice are …

… deficiency … , insulin resistance, and development of NAFLD in mice. Methods: We evaluated
liver histopathology, serum alanine aminotransferase (ALT), glucose, fatty acids, and insulin …

… insulin resistance development under all conditions. In parallel with systemic insulin resistance,
we uncovered that hepatic mitochondrial … the observation of mitochondrial dysfunction by …

… Recently, we demonstrated that a deficiency of Cisd2, an iron… the bioenergetic function of
mitochondria and the function of … aimed at preventing and treating insulin resistance and T2D. …