… a variety of insulin-resistant states. Children with severe insulin resistance often manifest
ovar… This syndrome is characterized by severe insulin resistance and often fatal developmental …

… the fed to the fasted state. The positive and … insulin in different tissues. Whereas genetic
mutations are causes of rare and severe insulin resistance, obesity can lead to insulin resistance …

… Our primary aim is to broadly highlight how insulin deficiency in T1D and insulin resistance
… can adversely affect insulin’s actions. We propose that impaired insulin secretion and action …

… of insulin produce a less than normal biologic response.’ Usually we speak of insulin
resistance in terms of the entire organism; however, insulin resistance may involve only a single …

… insulin-resistant states in humans remains a matter of speculation. One hypothesis is that
resistance to the normal suppressive effect of insulin, in … associated with insulin resistance, may …

… Insulin resistant states are commonly associated with an atherogenic dyslipidemia that …
in these patients is resistance to cellular actions of insulin, particularly resistance to insulin-…

… -promoting tissue effects in the face of limited insulin effect on glucose metabolism. Such
spillover actions may add to the morbidity associated with states of clinical insulin resistance. …

… insulin signaling pathways leading to glucose uptake, 2) review mouse models of insulin
resistance … for insulin resistance in some human disease states known to be associated with …

… to insulin are also very important. We studied the molecular basis of insulin resistance in mice
in … of hyperphagia, obesity and insulin resistance over a 4-month period. We found that the …

… insulin action and the pathophysiology of insulin resistance are described, focusing on three
key insulin … by which insulin’s effects are attenuated in the insulin-resistant state that heralds …