… and amplifying signals in β cells and stimulation of insulin secretion. The triggering signal …
]i changes in β cells, and the amplifying signal as the increase in insulin secretion produced by …

… associated with a reduced insulin secretion in relation to insulin sensitivity, and second…
insulin secretion has to be undertaken in relation to insulin sensitivity. The importance of beta cell …

… of β cells, … β cells result in severe alterations of this responsiveness. Thus, knockout of the
gene coding for the Igf1 receptor of β cells results in loss of glucose-induced insulin secretion […

… insulin release. This paper reviews the evidence in support of several new concepts and
hypotheses in the field of β-cell … explain the kinetics and extent of secretion induced by glucose: …

… β-cell function and, in particular, in glucose sensing. Moreover, models of β-cell ablation in
rodents suggest that non-β cells … express insulin and to respond to glucose with the secretion …

… that FFAs markedly amplified insulin secretion in response to all fuel … β-cell signaling
processes, in particular those involving lipid signaling. Thus, we recommend that insulin secretion …

… , biphasic insulin secretion has gradually been understood to reflect (5-cell rate sensitivity,
be important in minimizing overinsulinization in normal individuals, be defective in non-insulin-…

… We highlight salient differences between mouse and human β-cells, provide models of how
the … Much of our knowledge of insulin secretion comes from work on rodent islets and β-cells. …

… first-phase insulin secretion is clearly … β-cell glucose metabolism and insulin secretion
152,153 . Other GK mutations cause partial or complete loss of enzyme activity, resulting in insulin …

… of insulin secretion from human isolated beta cells and its regulation by cell-to-cell
contacts. … Insulin secretion of single beta cells was similar at 12.2 and 22.2 mmol/l glucose. …