… increased insulin secretion in 3 … insulin secretion in normal human islets is larger than
often reported. Its characteristics are globally similar to those of insulin secretion by rodent islets, …

… islets obtained from organ donors (5). As a by-product of the islet transplantation program,
more human islets … advances in our understanding of insulin secretion in human β cells. We …

… Basic characteristics of insulin secretion by the 22 preparations of human islets used in this
study. A–E: all perifusions started with a 60-min stabilization period, of which only the last 10 …

… proteins involved in glucose-regulated insulin secretion in human islets, we examined the …
human islets with an intact insulin secretory pattern. We also assessed these features in islets …

… recent studies in isolated islets, addresses a … human islets fit with our knowledge of insulin
secretion in man? The aims are not to discuss specificities of pathways controlling secretion …

… insulin action and a loss of the normal insulin secretion response to glucose. Glucose
stimulates insulin secretion … or amplifying phase of this secretory response, have been recently …

… pattern of glucose- induced insulin secretion is seen in isolated rodent and human islets,
suggesting that this characteristic pattern of insulin secretion is an intrinsic property of the islets. …

… that use these islets. In what is, to our knowledge, the first standardized assessment of human
islet preparations from multiple isolation centers, we measured insulin secretion from 202 …

… Stimulation of human islets with G15 induced biphasic insulin secretion (Figure 2A).8 Addition
of diazoxide during the second phase abolished secretion that was reversibly restored by …

… distributed throughout the islet.Despite this, human islets still require close cellular
communication between β-cells and the other islet cell types to regulate insulin secretion.These stud…