The importance of first‐phase insulin secretion: implications for the therapy of type 2 diabetes mellitus

S Del Prato, A Tiengo - Diabetes/metabolism research and …, 2001 - Wiley Online Library
insulin secretion and action. Insulin resistance is a key feature of type 2 diabetes. However,
… role of the first-phase of insulin secretion in the maintenance of postmeal glucose …

Pharmacological interventions that directly stimulate or modulate insulin secretion from pancreatic β‐cell: implications for the treatment of type 2 diabetes

A Farret, L Lugo‐Garcia, F Galtier… - Fundamental & …, 2005 - Wiley Online Library
… , others fail to respond to the treatment, and some develop serious … insulin secretion from
the pancreas or improving insulin … of insulin, with special emphasis on new ways of amplifying …

[HTML][HTML] Nutritional regulation of insulin secretion: implications for diabetes

P Newsholme, M Krause - The Clinical Biochemist Reviews, 2012 - ncbi.nlm.nih.gov
secretion coupling signals that promote insulin biosynthesis and release. The primary stimulus
for insulin secretion … agents on metabolism and insulin secretion and to also acknowledge …

Hydrogen sulfide in the regulation of insulin secretion and insulin sensitivity: Implications for the pathogenesis and treatment of diabetes mellitus

J Bełtowski, G Wójcicka… - Biochemical pharmacology, 2018 - Elsevier
insulin secretion by increasing intracellular cAMP concentration in β cells [11]. Insulin secretion
is … which innervates pancreatic islets modulates insulin secretion as well. In particular, …

Minireview: implication of mitochondria in insulin secretion and action

A Wiederkehr, CB Wollheim - Endocrinology, 2006 - academic.oup.com
insulin secretion and their utilization in peripheral tissues. … insulin secretion and participate
in the actions of insulin on its … the implication of mitochondria in normal metabolism secretion

The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus

WT Garvey, JM Olefsky, J Griffin, RF Hamman… - Diabetes, 1985 - Am Diabetes Assoc
insulin treatment resulted in enhanced postreceptor insulin action, decreased basal hepatic
glucose output, and improved endogenous insulin secretion in … implications regarding treat

Pharmacological agents that directly modulate insulin secretion

ME Doyle, JM Egan - Pharmacological reviews, 2003 - ASPET
… Insulinotropic agents may act either by direct stimulation of insulin secretion or by amplifying
insulin secretion induced by other means. Initiators of insulin secretion include glucose and …

Insulin secretion and insulin resistance in pregnancy and GDM: implications for diagnosis and management

C Kühl - Diabetes, 1991 - Am Diabetes Assoc
… the nonpregnant state, and the insulin responses to a protein-rich … insulin secretion exist
between pregnant women with normal glucose tolerance (NGT) and women with GDM. Insulin

Physiology and pathophysiology of insulin secretion

H Rasmussen, KC Zawalich, S Ganesan… - Diabetes …, 1990 - Am Diabetes Assoc
… pattern of insulin secretion is observed. … insulin secretion is dependent on periodic rather
than continuous exposure to the correct pattern of extracellular signals. The clinical implications

Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus

WK Ward, JC Beard, JB Halter, MA Pfeifer… - Diabetes …, 1984 - Am Diabetes Assoc
… Finally, the implications of this analysis for the treatment of … insulin secretion by causing
insulin resistance and hyperglycemia.'Ketones (ie, acetoacetate) stimulate insulin secretion in …