Control mechanisms of the oscillations of insulin secretion in vitro and in vivo

P Gilon, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc
… hypoglycemic effect of exogenous insulin when it is infused in … have impaired pulsatile
insulin secretion has prompted the … the pulsatility of insulin secretion both in vitro and in vivo. …

The in vivo regulation of pulsatile insulin secretion

N Pørksen - Diabetologia, 2002 - Springer
… This review will mainly focus on the rapid oscillatory insulin secretory pattern, and will
relate the observations of in vivo pulsatility to important aspects of oscillatory beta-cell function …

Insulin suppresses its own secretion in vivo

GM Argoud, DS Schade, RP Eaton - Diabetes, 1987 - Am Diabetes Assoc
insulin secretion (13). Our results demonstrate a dose-dependent suppression of insulin
secretion at two physiologic levels of plasma insulin … that basal insulin secretion is suppressed …

In Vivo and In Vitro Glucose-Induced Biphasic Insulin Secretion in the Mouse: Pattern and Role of Cytoplasmic Ca2+ and Amplification Signals in β-Cells

JC Henquin, M Nenquin, P Stiernet, B Ahren - Diabetes, 2006 - Am Diabetes Assoc
… Our in vitro studies further showed that the second phase of insulin secretion by mouse
islets is ascending when the protocol of stimulation is close to that in vivo, namely when the …

Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo

JA Cases, I Gabriely, XH Ma, XM Yang, T Michaeli… - Diabetes, 2001 - Am Diabetes Assoc
… the possibility of direct actions of leptin on insulin secretion. In vitro studies on islets or … vivo
study to distinctly examine whether leptin has an effect on glucose-stimulated insulin secretion

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo

MG Latour, T Alquier, E Oseid, C Tremblay… - Diabetes, 2007 - Am Diabetes Assoc
… The results of our experiments examining insulin secretion in vitro and in vivo in response to
… regarding the mechanisms of action of fatty acids on insulin release. On one hand, there is …

Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration

M Okamoto, M Ohara-Imaizumi, N Kubota… - Diabetologia, 2008 - Springer
… Adiponectin stimulates insulin secretion in vivo To elucidate the physiological roles of
adiponectin in insulin secretion in vivo, we studied the effect of adiponectin on insulin secretion in …

In vivo insulin secretion and action in hyperglycemic rat

MC Laury, L Penicaud, A Ktorza… - American Journal …, 1989 - journals.physiology.org
… to study the effects on insulin secretion and action in vivo of moderate … the infusion period,
plasma insulin-to-glucose … Glucose tolerance and insulin secretion tests were performed 2 h …

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets

JM Luther, P Luo, MT Kreger, M Brissova, C Dai… - Diabetologia, 2011 - Springer
… We assessed insulin sensitivity and insulin secretion in aldosterone synthase-deficient (As
[… We subsequently assessed the effect of aldosterone on insulin secretion in vitro in the …

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding

M Kebede, T Alquier, MG Latour, M Semache… - Diabetes, 2008 - Am Diabetes Assoc
… a role in insulin secretion after HFD, we measured insulin release in response to glucose
and Intralipid after 10 and 11 weeks, respectively, of HFD or regular diet. Insulin secretion in …