Insulin signaling as a therapeutic mechanism of lithium in bipolar disorder

IH Campbell, H Campbell, DJ Smith - Translational Psychiatry, 2022 - nature.com
… inhibitor fluoxetine on metabolic mechanisms [51] this line of research may also have the
potential to identify candidates for lithium augmentation during antidepressant treatment. An …

Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression

JB Price, CG Yates, BA Morath… - Translational …, 2021 - nature.com
… A similar correlation was observed in our prior work demonstrating lithium augmentation of …
peripheral insulin signaling [15]. In the current study, the upregulation of insulin signaling with …

Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of …

AJ Walker, JB Price, K Borreggine, SL Sutor… - Translational …, 2019 - nature.com
… In this study, we sought to verify that lithium augmentation … with the expression of insulin
signaling pathway proteins. ACTH … impact of lithium augmentation on insulin signaling in brain …

Leptin serum concentrations are associated with weight gain during lithium augmentation

R Ricken, S Bopp, P Schlattmann, H Himmerich… - …, 2016 - Elsevier
… In summary our results suggest that leptin signaling may be involved in lithium-induced
weight gain. Further studies are needed to light on the specific role of leptin in lithium induced …

[HTML][HTML] Beyond its psychiatric use: the benefits of low-dose lithium supplementation

SI Hamstra, BD Roy, P Tiidus, AJ MacNeil… - Current …, 2023 - ncbi.nlm.nih.gov
… While our study is not the first to showcase the myoblast fusion augmenting effect of Li, it is
… production, the enhancement of the insulin signaling cascade, GLUT4 translocation, as well …

Dynamic insulin‐stimulated mTOR/GSK3 signaling in peripheral immune cells: Preliminary evidence for an association with lithium response in bipolar disorder

SJ Tye, K Borreggine, JB Price, SL Sutor… - Bipolar …, 2022 - Wiley Online Library
… hypothesis, showing that prefrontal insulin signaling under stress directly correlated with
antidepressant-like behavioral response to lithium augmentation in antidepressant-resistant rats…

[HTML][HTML] Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis

SR Jung, JH Lee, H Ryu, Y Gao… - The Korean Journal of …, 2024 - synapse.koreamed.org
… However, lithium did not augment the effect of an exercise on … insulin signaling changes
after an exercise and/or lithium … , which was reversed after lithium administration, whereas an …

Lithium and neuropsychiatric therapeutics: neuroplasticity via glycogen synthase kinase-3β, β-catenin, and neurotrophin cascades

A Wada - Journal of pharmacological sciences, 2009 - jstage.jst.go.jp
… expression of insulin-like growth factor-I, while insulin-like … raise transport of peripheral
circulating insulin-like growth factor … lithium, GSK-3β/β-catenin, and neurotrophin cascades. …

Endocrinological disorders related to the medical use of lithium. A narrative review

G García-Maldonado… - Revista Colombiana de …, 2019 - Elsevier
… of manic episodes, and as an augmentation agent for depressive symptoms, 1 irrespective
of … of insulin release. Peripheral lithium has been associated with a similar effect to insulin in …

Intracellular pathways underlying the effects of lithium

L Pasquali, CL Busceti, F Fulceri… - Behavioural …, 2010 - journals.lww.com
… is involved in regulating GSK-3β is the insulin signaling pathway (Fig. 7). … insulin signaling.
In fact GSK-3β acts as an inhibitor for insulin receptor substrate-1 (an inhibitor of the insulin