… We found that viral replication was severely or completely compromised by many of the
mutations. We further show that a second mutation in integrase can compensate for mutations in …

… to SV40-HIV integrase mutant replication. SV40-based HIV-1 integrase mutant replication in
… alternative approaches to standard integrase-mediated retroviral gene transfer strategies. …

… fail to inhibit human immunodeficiency virus (HIV) replication or … simian virus 40-HIV
integrase mutant chimera as a novel tool to classify the mechanism of action of potential integrase …

… Full-site integration by recombinant wild-type and mutant simian immunodeficiency virus (SIV)
integrase (IN) was investigated with linear retrovirus-like DNA (469 bp) as a donor …

… (Stratagene) was used to generate desired mutations in the integrase region of stHIV-1 using
… The presence of the mutations in the integrase region of stHIV-1 (SCA,SVIF) was confirmed …

… HIV integrase resistance-associated mutations … integrase enzyme catalytic activities, we
also provide the first research anywhere on the effect of mutations within recombinant integrase …

… For each individual animal, the earliest detection of integrase mutations is indicated (arrow);
the main mutations observed at the end of the study are summarized on the top right of each …

… -negative mutants of HIV-1 could not generate infectious virus, our results show that an
integrase-negative SIV mutant can, upon infection of appropriate cells, produce infectious …

… If these represent autointegration products, their levels should decrease when the activity of
the viral integrase is inhibited. Raltegravir is a strand transfer inhibitor of retroviral integrases …

… of integrase, a … simian immunodeficiency virus (SIV) integrase that contains a contiguous
core and DBD, to encompass amino acid residues 50-293 and a site-specific F185H mutation (…