An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes

S Ghaffari, C Hanson, RE Schmidt, KJ Bouchonville… - Genome biology, 2021 - Springer
… We present here a comprehensive multi-omics approach to investigate the cis-regulatory
mechanisms underlying the biological processes marked by large-scale transcriptomic changes…

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

ML Colli, M Ramos-Rodríguez, ES Nakayasu… - Nature …, 2020 - nature.com
… In conclusion, we have applied a multi-omics approach to study the different levels of gene
regulation induced by IFNα in EndoC-βH1 cells and pancreatic human islets. This in vitro …

A network-based cancer drug discovery: from integrated multi-omics approaches to precision medicine

B Turanli, K Karagoz, G Gulfidan… - Current …, 2018 - ingentaconnect.com
… followed by integration of multi-omics data using various biological networks. Next, we
provide an opening into precise medicine and drug targeting based on network approaches. …

Integrated multi-omics approaches to improve classification of chronic kidney disease

S Eddy, LH Mariani, M Kretzler - Nature Reviews Nephrology, 2020 - nature.com
… Such studies have led to a subsequent increase in the number of integrative multi-omics
studies that have the potential to enhance our understanding of the molecular processes that …

Multi-omics data integration, interpretation, and its application

I Subramanian, S Verma, S Kumar… - … and biology insights, 2020 - journals.sagepub.com
… Herein, we discuss in detail the tools and their methods that allow integration of multi-omics
data sets to address the various challenges related to disease and their mechanisms. The …

Multi-omics approaches to disease

Y Hasin, M Seldin, A Lusis - Genome biology, 2017 - Springer
… on the integration of multiple types of omics data (“multi-omics” or … Second, we discuss general
frameworks for integration of omics … about the future directions of multi-omics approaches. …

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease

R Nativio, Y Lan, G Donahue, S Sidoli, A Berson… - Nature …, 2020 - nature.com
… Given the complexity of the aging and neurodegenerative processes, and their interrelation,
we performed a comprehensive multi-omics analysis of brains affected with AD versus the …

Integrative network fusion: a multi-omics approach in molecular profiling

M Chierici, N Bussola, A Marcolini… - Frontiers in …, 2020 - frontiersin.org
… This work proposes multi-omics integration as an approach to identify robust biomarkers of
… Thus, each feature f i is associated to a consistency score, ranking all multi-omics features …

[HTML][HTML] Integrative multi-omics approaches in cancer research: from biological networks to clinical subtypes

YJ Heo, C Hwa, GH Lee, JM Park, JY An - Molecules and cells, 2021 - Elsevier
… concept of multi-omics approaches in … a multi-omics approach to uncover novel concepts
and properties. We also discuss some of the challenges connected to multi-omics approaches

Integrative multi-omics approaches to explore immune cell functions: Challenges and opportunities

X Wang, D Fan, Y Yang, RC Gimple, S Zhou - IScience, 2023 - cell.com
… Derived from these multi-omics technologies, single cell sequencing analysis on … in
multi-omics tools to explore immune cell functions and applications of these multi-omics approaches