… Here, we report the localization of mRNA to stress granules (SGs) and processing bodies (…
and degradation during the integrated stress response. Using single mRNA imaging in living …

… of mRNAs. The mechanism that allows preferential translation upon ISR activation was first
elucidated over 25 years ago for the yeast mRNA encoding the stress response transcription …

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response ( ISR ), to restore cellular homeostasis. The core event …

… of mRNAs for components of the integrated stress response as true NMD targets predicts that
these mRNAs … bodies, we next examined the localization of Rent1/Upf1 in mammalian cells …

… integrated stress response (ISR), a pro-survival gene expression program. Previous studies
implicated the 5′ end of the ATF4 mRNA, … analysis of the ATF4 mRNA which revealed that …

… and its effect on translation and mRNA degradation during the integrated stress response.
Using single mRNA imaging in living human cells, we find that the interactions of mRNAs with …

… translation of a subset of mRNAs that contain uORFs, such as ATF4 mRNA. To test the …
trigger (ie, viral dsRNA) with natural intracellular localization and in physiological quantities. We …

… integrated stress response. Restimulation of the cells resulted in rapid eIF2α dephosphorylation,
ribosomal mRNA … by our observations of the positioning of BiP in the polysome profile …

… Here, we report on an ATF4-mediated integrated stress response initiated by eIF2α … protects
cells against oxidative stress. Activation of this integrated stress response is shown to have a …

… factor that is localized to the ER and serves as both a sensor of ER stress and a … of XBP1
mRNA and, as a consequence the amount of spliced XBP1 mRNA in response to ER stress, the …