… The mechanism of substrate hydrolysis by CEs. The essential catalytic amino acids are shown
(Ser, His and Glu) and the mechanism depicts the hydrolysis of a generic ester (RCOOR 1 …

… Toxicities may arise from the interaction of these compounds … composed of both paraoxonases
and carboxylesterases (CEs). … in vivo can be regulated by several mechanisms, including …

… signal peptide, microsomal carboxylesterases can be released … mammalian CEs including
human carboxylesterase 1 (CES1) … These features make CES1 capable of interacting with a …

… drug interaction involving a mechanism of a carboxylesterase substrate metabolism was the
interaction … understanding of drug interactions involving carboxylesterase substrates and the …

… Human carboxylesterases (hCEs) are classified into two subtypes, human carboxylesterase
1 (hCE 1) and human carboxylesterase 2 (hCE 2) (Xin et al., 2018). hCE 1 is abundantly …

… (1, 7, 13, and 25) from this herbal showed remarkable inhibitory activities against CES 2,
which elicited our interests in exploring their inhibition behavior and interaction mechanism. …

In this study, forty-nine kinds of traditional Chinese medicines (TCMs) were evaluated for
their inhibitory activities against human carboxylesterase 2 (HCE 2) using a human liver …

… human carboxylesterase 2 (hCE 2) inhibitors from natural products, we investigated inhibitory
effects and mechanisms of … the view of ligand-enzyme interactions, molecular docking was …

… for natural human carboxylesterase 2 (human CES 2) … extract of Alisma orientale significantly
inhibited human CES 2 in vitro. … potential interaction mechanism of compound 1 with human …

… metabolism based upon their interactions with three major … are involved in insecticide
resistance mechanisms. It is well … the stereospecific interactions of human carboxylesterase 1 (…