Identification of prognostic biomarker signatures and candidate drugs in colorectal cancer: insights from systems biology analysis

MR Rahman, T Islam, E Gov, B Turanli, G Gulfidan… - Medicina, 2019 - mdpi.com
… –protein interaction and transcriptional/post-transcriptional regulatory networks to identify
matrix (ECM) interaction, and cell cycle were identified as significantly enriched pathways. …

[HTML][HTML] Identification of hub genes, key miRNAs and potential molecular mechanisms of colorectal cancer

S Wu, F Wu, Z Jiang - Oncology Reports, 2017 - spandidos-publications.com
Colorectal cancer (CRC) is the most common cancer of the digestive system. The aim of the
present study was to identify … Combination of mRNAs, miRNAs and interaction networks can …

Identification of potential hub genes via bioinformatics analysis combined with experimental verification in colorectal cancer

H Zhou, Z Yang, J Yue, Y Chen, T Chen… - Molecular …, 2020 - Wiley Online Library
Colorectal cancer (CRC) is a kind of malignant cancer with … the protein-protein interaction
network were constructed, and … COmplex DEtection algorithm to find out the core interaction in …

[HTML][HTML] Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer

Z Liu, S Weng, Q Dang, H Xu, Y Ren, C Guo, Z Xing… - Elife, 2022 - ncbi.nlm.nih.gov
… -based program, we identified and diversely validated six gene interaction … (E)
Metabolite-protein interaction network (MPIN) was established via nine GINS6-specific genes with …

Functional and protein‑protein interaction network analysis of colorectal cancer induced by ulcerative colitis

Y Dai, JB Jiang, YL Wang… - Molecular Medicine …, 2015 - spandidos-publications.com
… Protein-protein interaction network of colorectal cancer DE genes. A total of 210 node (purple
ovals) and 752 edges (lines between) were identified, which included 217 DE genes. …

Prediction and validation of hub genes associated with colorectal cancer by integrating PPI network and gene expression data

Y Xiong, W You, R Wang, L Peng… - BioMed research …, 2017 - Wiley Online Library
… The aim of this study was to identify the hub genes based on protein-protein interaction
network … Subsequently, we investigated the substructure of the giant protein interaction network

Identification of core gene expression signature and key pathways in colorectal cancer

X Ding, H Duan, H Luo - Frontiers in genetics, 2020 - frontiersin.org
… using R software for the comprehensive identification of differentially expressed genes (DEGs).
Then, we established a protein–protein interaction (PPI) network of DEGs to screen out …

A network-based gene expression signature informs prognosis and treatment for colorectal cancer patients

M Shi, RD Beauchamp, B Zhang - PloS one, 2012 - journals.plos.org
… mutation data on a protein-protein interaction network, we show that the CRC recurrence …
data on a protein-protein interaction network in order to identify genes of potential mechanistic …

Identification of key gene targets for sensitizing colorectal cancer to chemoradiation: an integrative network analysis on multiple transcriptomics data

H Manoochehri, A Jalali, H Tanzadehpanah… - … gastrointestinal cancer, 2022 - Springer
… Hub genes are the nodes in protein–protein interaction networks that … network analysis
on different microarray datasets for identifying crucial genes associated with colorectal cancer

Identification of key candidate genes for colorectal cancer by bioinformatics analysis

Z Chen, Y Lin, J Gao, S Lin, Y Zheng… - Oncology …, 2019 - spandidos-publications.com
Colorectal cancer (CRC) is one of the most common cancers of the … interaction network
was constructed, and the hub genes were subjected to module analysis and identification