… class II molecules and of HLA-DM have not permitted identification of their interaction sites.
Here, we describe mutations in class II that impair interactions with DM. Libraries of randomly …

… In the period covered by this review, significant progress has been made towards
understanding the structural basis for DM interaction with MHC-II, and new work strengthens the …

… modulates HLA-DM function. We determined the X-ray crystal structure of HLA-DO bound to
HLA-DM … We measured the interaction of soluble DO and DM using biolayer interferometry. …

… minimisation simulations to identify a putative interaction site of >4000 Å 2 which agrees
with known point mutational data for both the DR and DM molecule. The docked structure is …

… DM mutations identified an interaction surface, we mapped them on the crystal structure of
HLA-DM (… All six are surface exposed and located on the same lateral face of DM, with βE8, …

… -DR2 variants, indicating that DM specifically binds DR molecules in which the N-terminal
site of the complex is emptied.51 Indeed, this study clearly showed that DM did not interact …

… Additionally, we examine the in vitro interaction of affinity-purified DM with DR molecules …
for αβCLIP in the interaction, and suggest that one function of HLA-DM is to prolong the survival …

… (B and E) Top view of the DM-DR1 complex shows the DM interaction site on the DRα chain
and a partially empty peptide-binding groove. DMα is colored red, DMβ yellow, DRα cyan, …

… These data are consistent with the observation of a transient interaction between DM and
DR`, irrespective of loading with cognate peptide or CLIP (21). The primary sequence of the …

… As in the HLA-DM-HLA-DO structure, αW43 in HLA-DR1 rotates out of the lateral wall of
P1 pocket to directly interact with HLA-DM by forming a hydrogen bond with HLA-…