Determination of the HLA-DM interaction site on HLA-DR molecules
… in DR α or β chains that lead to a loss of interaction with HLA-DM. We predicted that this should
result in surface accumulation of CLIP/DR … cells with mutant DR3 molecules, followed by …
result in surface accumulation of CLIP/DR … cells with mutant DR3 molecules, followed by …
Identification of the HLA-DM/HLA-DR interface
MN Davies, A Lamikanra, CE Sansom, DR Flower… - Molecular …, 2008 - Elsevier
… DM–DR interaction site, in conjunction with known experimental data, offers a convincing
argument that the genuine interaction between the two molecules strongly resembles the …
argument that the genuine interaction between the two molecules strongly resembles the …
Use of T cell receptor/HLA‐DRB1* 04 molecular modeling to predict site‐specific interactions for the DR shared epitope associated with rheumatoid arthritis
JE Penzotti, GT Nepom… - Arthritis & Rheumatism …, 1997 - Wiley Online Library
… , which is specific for DR4 molecules containing the shared epitope sequence. Interactive
graphics techniques were used to orient the TCR on the DR molecule, guided by surface …
graphics techniques were used to orient the TCR on the DR molecule, guided by surface …
HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide
AK Anders, MJ Call, MSED Schulze, KD Fowler… - Nature …, 2011 - nature.com
… The proximity of the HLA-DM-interaction site to the N terminus of the … HLA-DR–peptide
conformers interact with HLA-DM. We report here that the interaction of HLA-DM with HLA-DR …
conformers interact with HLA-DM. We report here that the interaction of HLA-DM with HLA-DR …
HLA-DR: molecular insights and vaccine design
LJ Stern, JM Calvo-Calle - Current pharmaceutical design, 2009 - ingentaconnect.com
… the site. This conformation places several of the peptide side chains into pockets within the
… site, and directs others outward for interaction with the T cell receptor antigen binding site (Fig…
… site, and directs others outward for interaction with the T cell receptor antigen binding site (Fig…
Role of the polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligands.
KW Marshall, AF Liu, J Canales, B Perahia… - … (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
… proteins, P9 and P11 seem to point down and contact adjacent p strands, with P10 pointing
out of the site and interacting with the TCR. Therefore, we placed the side chain of the 9th …
out of the site and interacting with the TCR. Therefore, we placed the side chain of the 9th …
Molecular analysis of thymopentin binding to HLA-DR molecules
… Here, we performed molecular modeling evaluations to analyze the interaction between the
anchors in the frame of TP5 and the binding sites within the groove of HLA-DR. The alanine …
anchors in the frame of TP5 and the binding sites within the groove of HLA-DR. The alanine …
Identification of a CD4 binding site on the β2 domain of HLA-DR molecules
G Cammarota, A Scheirle, B Takacs, DM Doran… - Nature, 1992 - nature.com
… To determine whether the DR8 chain alone was able to interact specifically with the CD4
molecule, we infected Sf9 cells with baculoviruses carrying the hybrid DR48–DAF gene. No …
molecule, we infected Sf9 cells with baculoviruses carrying the hybrid DR48–DAF gene. No …
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
… the site without styles and JavaScript. … HLA-DRB1–HLA-DQA1–HLA-DQB1 locus.
Additionally, we observed significant interactions for 11 of 21 pairs of common HLA-DRB1–HLA-DQA1–…
Additionally, we observed significant interactions for 11 of 21 pairs of common HLA-DRB1–HLA-DQA1–…
[HTML][HTML] Crystal structure of the HLA-DM–HLA-DR1 complex defines mechanisms for rapid peptide selection
… -DR1 complex shows the DM interaction site on the DRα chain … Peptide and the DR αV65C
covalent attachment site are … as surfaces, emphasizing interactions between DRα and DMα …
covalent attachment site are … as surfaces, emphasizing interactions between DRα and DMα …
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