Interactive associations of vascular risk and β-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the Harvard Aging Brain …

JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA …, 2018 - jamanetwork.com
… that vascular risk has a potent association with longitudinal cognitive decline, both alone and
synergistically with Aβ burden in clinically normal older adults. Vascular risk … of vascular risk

Association of vascular risk factors with β-amyloid peptide and tau burdens in cognitively unimpaired individuals and its interaction with vascular medication use

T Köbe, J Gonneaud, AP Binette, PF Meyer… - JAMA network …, 2020 - jamanetwork.com
… We did not observe associations between individual vascular risk factors and cerebral or
CSF tau accumulation, but vascular medication use showed an interaction with the association

Association between midlife vascular risk factors and estimated brain amyloid deposition

RF Gottesman, ALC Schneider, Y Zhou, J Coresh… - Jama, 2017 - jamanetwork.com
… and vascular risks. These relationships are further complicated by the direct association
between APOE and vascular … of the interactive effects of APOE and vascular risk factors on AD …

Interactive effects of vascular risk burden and advanced age on cerebral blood flow

KJ Bangen, DA Nation, LR Clark, AL Harmell… - Frontiers in aging …, 2014 - frontiersin.org
… Among older adults with multiple vascular risk factors, we found association between
advancing age and reduction in CBF in cortical regions implicated in early AD. Evidence suggests …

Vascular risk and β‐amyloid are synergistically associated with cortical tau

JS Rabin, HS Yang, AP Schultz… - Annals of …, 2019 - Wiley Online Library
… study we examined associations between vascular risk factors, … interactive association with
subsequent tau burden in 2 predefined ROIs (EC and ITC). We found a significant interaction

Tau mediates synergistic influence of vascular risk and Aβ on cognitive decline

WYW Yau, Z Shirzadi, HS Yang, AP Ikoba… - Annals of …, 2022 - Wiley Online Library
vascular risk factors were driving this interaction with Aβ on longitudinal tau, we conducted
post hoc analyses to investigate the interactive … find associations between vascular risk and …

Associations of vascular risk and amyloid burden with subsequent dementia

RF Gottesman, A Wu, J Coresh… - Annals of …, 2022 - Wiley Online Library
interaction between vascular risk or vascular markers and brain amyloid, with the poorest
cognitive outcomes in individuals with both elevated vascular risk and brain amyloid. …

Association of β-amyloid and vascular risk on longitudinal patterns of brain atrophy

JS Rabin, J Pruzin, M Scott, HS Yang, O Hampton… - Neurology, 2022 - AAN Enterprises
… A final goal of the study was to determine whether the interactive association of vascular risk
vascular risk–Aβ interaction (described above) and PACC decline. Significant associations

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease

M Kivipelto, T Ngandu, L Fratiglioni… - Archives of …, 2005 - jamanetwork.com
vascular risk factors with dementia and AD in late life in both sexes. Herein, we first evaluated
the association … We did not find significant interaction between sex and BMI for dementia, …

Vascular risk factors: imaging and neuropathologic correlates

DS Knopman, R Roberts - Journal of Alzheimer's disease, 2010 - content.iospress.com
… There appears to be no interactive effect on dementia severity … that such an interactive
mechanistic pathway exists. … factor is “associated with AD,” that really means “associations with a …