Interactive associations of vascular risk and β-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the Harvard Aging Brain …
JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA …, 2018 - jamanetwork.com
… that vascular risk has a potent association with longitudinal cognitive decline, both alone and
synergistically with Aβ burden in clinically normal older adults. Vascular risk … of vascular risk …
synergistically with Aβ burden in clinically normal older adults. Vascular risk … of vascular risk …
Association of vascular risk factors with β-amyloid peptide and tau burdens in cognitively unimpaired individuals and its interaction with vascular medication use
T Köbe, J Gonneaud, AP Binette, PF Meyer… - JAMA network …, 2020 - jamanetwork.com
… We did not observe associations between individual vascular risk factors and cerebral or
CSF tau accumulation, but vascular medication use showed an interaction with the association …
CSF tau accumulation, but vascular medication use showed an interaction with the association …
Association between midlife vascular risk factors and estimated brain amyloid deposition
… and vascular risks. These relationships are further complicated by the direct association
between APOE and vascular … of the interactive effects of APOE and vascular risk factors on AD …
between APOE and vascular … of the interactive effects of APOE and vascular risk factors on AD …
Interactive effects of vascular risk burden and advanced age on cerebral blood flow
… Among older adults with multiple vascular risk factors, we found association between
advancing age and reduction in CBF in cortical regions implicated in early AD. Evidence suggests …
advancing age and reduction in CBF in cortical regions implicated in early AD. Evidence suggests …
Vascular risk and β‐amyloid are synergistically associated with cortical tau
… study we examined associations between vascular risk factors, … interactive association with
subsequent tau burden in 2 predefined ROIs (EC and ITC). We found a significant interaction …
subsequent tau burden in 2 predefined ROIs (EC and ITC). We found a significant interaction …
Tau mediates synergistic influence of vascular risk and Aβ on cognitive decline
… vascular risk factors were driving this interaction with Aβ on longitudinal tau, we conducted
post hoc analyses to investigate the interactive … find associations between vascular risk and …
post hoc analyses to investigate the interactive … find associations between vascular risk and …
Associations of vascular risk and amyloid burden with subsequent dementia
… interaction between vascular risk or vascular markers and brain amyloid, with the poorest
cognitive outcomes in individuals with both elevated vascular risk and brain amyloid. …
cognitive outcomes in individuals with both elevated vascular risk and brain amyloid. …
Association of β-amyloid and vascular risk on longitudinal patterns of brain atrophy
… A final goal of the study was to determine whether the interactive association of vascular risk
… vascular risk–Aβ interaction (described above) and PACC decline. Significant associations …
… vascular risk–Aβ interaction (described above) and PACC decline. Significant associations …
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
M Kivipelto, T Ngandu, L Fratiglioni… - Archives of …, 2005 - jamanetwork.com
… vascular risk factors with dementia and AD in late life in both sexes. Herein, we first evaluated
the association … We did not find significant interaction between sex and BMI for dementia, …
the association … We did not find significant interaction between sex and BMI for dementia, …
Vascular risk factors: imaging and neuropathologic correlates
DS Knopman, R Roberts - Journal of Alzheimer's disease, 2010 - content.iospress.com
… There appears to be no interactive effect on dementia severity … that such an interactive
mechanistic pathway exists. … factor is “associated with AD,” that really means “associations with a …
mechanistic pathway exists. … factor is “associated with AD,” that really means “associations with a …
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