Interferon-α as an immunotherapeutic protein
DL Brassard, MJ Grace… - Journal of leukocyte …, 2002 - academic.oup.com
… This concept serves to emphasize the potentially important role that a low-dose, systemic,
therapeutic administration of IFN-α during antineoplastic or antiviral treatment may serve …
therapeutic administration of IFN-α during antineoplastic or antiviral treatment may serve …
IFN λ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFN α treatment
… In epithelia, both IFNs induced antiviral genes but no inflammatory cytokines. … IFNα and
IFNλ by induction of antiviral genes but not of cytokines, while hPBMCs responded only to IFNα. …
IFNλ by induction of antiviral genes but not of cytokines, while hPBMCs responded only to IFNα. …
Anti-interferon alpha treatment in SLE
KA Kirou, E Gkrouzman - Clinical immunology, 2013 - Elsevier
… Targeting pDC to block their IFNα production is expected to not affect the IFN-I response in
other cells and therefore not compromise anti-viral defense as much as anti-IFNα strategies [6]…
other cells and therefore not compromise anti-viral defense as much as anti-IFNα strategies [6]…
Effect of interferon-alpha-based antiviral therapy on hepatitis C virus-associated glomerulonephritis: a meta-analysis
B Feng, G Eknoyan, Z Guo, M Jadoul… - Nephrology Dialysis …, 2012 - academic.oup.com
… antiviral treatment, making it difficult to determine the actual differential effect of each treatment
… Our meta-analysis shows that antiviral treatment based on IFNα can decrease protein …
… Our meta-analysis shows that antiviral treatment based on IFNα can decrease protein …
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy
AU Neumann, NP Lam, H Dahari, DR Gretch, TE Wiley… - Science, 1998 - science.org
… C virus and the antiviral effect of interferon-α-2b (IFN), viral … The analysis indicates that
the major initial effect of IFN is to … Because the clearance rate before treatment should be the …
the major initial effect of IFN is to … Because the clearance rate before treatment should be the …
[HTML][HTML] … among ribavirin plus interferon-alpha, lopinavir/ritonavir plus interferon-alpha, and ribavirin plus lopinavir/ritonavir plus interferon-alpha in patients with mild …
YQ Huang, SQ Tang, XL Xu, YM Zeng, XQ He… - Frontiers in …, 2020 - frontiersin.org
… effectiveness of three antiviral treatment regimens in patients … +IFN-α-treated group, as
compared with 13 and 15 d in the RBV+IFN-α-treated group and in the RBV+LPV/r+ IFN-α-treated …
compared with 13 and 15 d in the RBV+IFN-α-treated group and in the RBV+LPV/r+ IFN-α-treated …
Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C
JM Pawlotsky - Antiviral research, 2003 - Elsevier
… with phenomena that protect HCV from the antiviral action of IFN-α and hinder the clearance
of infected cells. This article discusses current knowledge of the mechanisms of action of …
of infected cells. This article discusses current knowledge of the mechanisms of action of …
Interferon‐alpha position in combating with COVID‐19: A systematic review
… patients who received standard antiviral treatment (lopinavir/… 23±10.5 days) in the combination
group with IFN α-2b was … , we indicated that IFN-α in combination with antiviral drugs …
group with IFN α-2b was … , we indicated that IFN-α in combination with antiviral drugs …
[HTML][HTML] Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus
E Miyaki, N Hiraga, M Imamura, T Uchida, H Kan… - PLoS …, 2017 - journals.plos.org
… Based on our results, we hypothesized that an indirect effect of IFN in our mouse model
was to enhance antiviral activity without damaging human hepatocytes. First, we analyzed the …
was to enhance antiviral activity without damaging human hepatocytes. First, we analyzed the …
Antiviral response by natural killer cells through TRAIL gene induction by IFN–α/β
K Sato, S Hida, H Takayanagi, T Yokochi… - European journal of …, 2001 - Wiley Online Library
… (s) by which IFN‐α/β contribute to the NK‐cell‐mediated antiviral … of NK cells is enhanced
by IFN‐α/β through induction of TNF‐… IFN‐α/β signaling and activation of NK cells in antiviral …
by IFN‐α/β through induction of TNF‐… IFN‐α/β signaling and activation of NK cells in antiviral …
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