… picture of how the IFN-α/β responses might act to shape adaptive immune responses under
a … that are poor inducers of IFN-α/β production, or controlled viral infections, expression of …

… /βR −/− mice have yielded information regarding the regulation of the immune system by
IFN-α to control viral infection. Although these mice have an otherwise normal …

… In this review, we discuss new insights into the antiviral functions of IFN-λ, especially those
distinguishing it from IFN-α/β. We also describe how IFN-λ modulates adaptive immunity, …

… immune responses. However, it is not completely understood how innate immunity controls
the initiation of adaptive immunities or how it determines which type of adaptive immunity …

… immunity to viral infections includes prominent CD8 T cell expansion and activation, and IFNr
… Innate cytokine responses can shape or control the endogenous T cell responses to these …

… IFN-γ response, there isno reason at present to attribute any of it to any other function except
theregulation of the immune system and the control of … for IFN-γ itself(17), for the essential α-…

… -γ and B cell production of IgG 2a antibodies were consistently lower in IFN-α/βR-deficient
mice compared with controls, implying that IFN-α/β plays a role in the polarisation of immune …

… CD4 + T cells in the immune control of Mtb infection (1, 2). CD4 + T cells secrete IFN-γ that in
turn … IFN-γ–induced expression of the antimicrobial enzyme NOS2 (3) is largely considered …

… type I IFN in the natural immune control of tumor growth. In fact, the low levels of spontaneous
IFN-α/β expressed under physiological conditions, as well as the enhanced IFN production …

… for efficient induction of IFNα/β genes by viruses,31) which we will discuss in detail below. …
that the constitutive, weak IFNα/β signalling should be controlled by a proper regulatory …