… lead to IFN production as well as the importance of IFN timing … mechanisms that SARS-CoV-2
uses to evade IFN responses, … SARS-CoV-2 and IFN to better inform treatments that exploit …

… III IFNs at multiple levels, including the induction of IFN expression and cellular responses to
IFNs. … of SARS-CoV-2 and the mechanisms used by SARS-CoV-2 to evade type I and III IFN …

… SARS-CoV-2 and influenza A virus in human airway epithelial cultures, we observe the absence
of IFN-I stimulation by SARS-CoV-… ISG induction in IFN-I-pretreated SARS-CoV infection …

… Inhibition of IFN-I production is pronounced in SARS-CoV-2 infection, … IFN-I offers a narrow
time window for efficacy and safety. Here, we discuss how limits placed on IFN-I by SARS-CoV…

… SARS-CoV-2 induces overt but delayed type-I interferon (IFN) … To understand the interaction
between SARS-CoV-2 and the … SARS-CoV-2 infection induces the expression of IFN-β and …

… Examining Vero cell protein lysates, we found that IFN-I treated cells infected with 107
SARS-CoV-2 induced phosphorylated STAT-1 by 48 hours post infection (Fig. 2). STAT1 108 …

… acute respiratory syndrome (SARS) has boosted … coronavirus termed SARS-CoV, employs
multiple passive and active mechanisms to avoid induction of the antiviral type I interferons in …

… of type I interferon (IFN), but … SARS-CoV could inhibit IFN-beta (IFN-β) induced by poly(I:C)
or Sendai virus. However, we found that N protein could not inhibit IFN-β production induced …

… (KRT18) promoter predominantly in epithelial cells are susceptible to SARS-CoV-2 [87]. Type
I IFN induction was detected in the lungs of SARS-CoV-2-infected K18-hACE2 mice, which …

… SARS-CoV-2 proteins that antagonize type I interferon (IFN-I) response. We found three
proteins that antagonize IFN… kinase 1 (TBK1) to suppress interferon regulatory factor 3 (IRF3) …