… and developments regarding IFN-activated JAK–STAT pathways, but the main focus is
the mechanisms of activation and the functional roles of non-STAT pathways in IFN-mediated …

… a well-balanced level of type I IFNs for … type I interferons in the CNS, focusing on possible
signaling cascades. The CNS cell types that are particularly susceptible to respond to type I IFN …

… Antiviral activity, which is stimulated by minute amounts of IFN-1 and is common to all cells,
is termed … basis for various IFN-1 activities, with emphasis toward the less common pathways. …

… IFN-λ could indicate that we still have an incomplete picture of the mechanisms that regulate
type III IFN … cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138(…

… type I IFN pathway in the peripheral blood and disease-affected tissues of each disease and
to correlate activation of this pathway in … a common molecular diagnostic to predict type I IFN …

… II (Pol II) at genes that encode IFN pathway components 19 and the induction of microRNAs
(… Various receptor pathways cross-regulate the type I interferon (IFN) response; this alters the …

… type I interferon in rheumatic diseases. We also examine genetic factors related to the type I
interferon pathway, focusing on common … type I interferons and the type I interferon pathway …

… for key molecules of the three different pathways of type I IFN gene activation was reported
( … their evolutional origin, IFN-λ genes are regulated by a mechanism common to type I IFNs. …

… IFN-responsive genes and (2) disease-associated SNPs of IFN-related genes, especially IRF5
(IFN-… Lastly, we discuss how such genetic alterations in type I IFN pathway fit in the current …

… type I interferon (IFN) pathway in the pathogenesis of the syndrome, as evidenced by the
increased circulating type I IFN activity and an IFN “… involved in the IFNα pathway, such as IRF5 …