… are associated with phenotypes of severe SARS-CoV disease. ► SARS-CoV proteins that
modulate innate immune responses antagonize the Interferon response and avoid detection …

… by which the SARS-CoV-2 virus antagonizes IFN action; and how genetic variability of
SARS-CoV-2 and the human host affects the IFN response at the level of IFN production or action …

… signature of interferon-… in SARS-CoV and MERS-CoV should be used with caution. Our
findings provide a better understanding of SARS-CoV-2 regulation of cellular interferon response …

… Type-I interferon signaling was identified as the common dysregulated cellular response in
… , and cellular response to SARS-CoV-2 and provide important clues to guide future studies. …

… responses. Here, we summarize the growing knowledge about the interplay of SARS-CoV-2 …
the regulation of type-I or -III interferon responses that are critically implicated in COVID-19 …

… We tested the effect of type I IFN against SARS–CoV-2 compared with the SARS–CoV-1
from 2003. Two different cell lines were employed, namely the human bronchial epithelial Calu-…

… of SARS-CoV-2 infection showed that IFN-I responses were … , when analysing the
transcriptomes of SARS-CoV-2-infected … also reported that IFN-I responses are highly impaired in …

… leading to SARS-CoV-2 pathogenesis. Regarding the role of the IFN response in SARS-CoV-2
infection, in this review we summarize the mechanisms by which SARS-CoV-2 evades …

… Given the complexity of IFN responses in SARS-CoV-2 infection, further insight into their
impact on the disease is of the utmost importance for continued development of drugs targeting …

… SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). Treatment with IFN-α or
IFN-… Further work is warranted to investigate the IFN response during SARS-CoV-2 infection to …