… IFN induction in response to SARS-CoV-2 infection. Further analyses revealed that viral
intermediates specifically activate the IFN response … the IFN response during SARS-CoV-2 …

… the adaptive immune response and … IFN-I offers a narrow time window for efficacy and
safety. Here, we discuss how limits placed on IFN-I by SARS-CoV-2 shape the immune response …

… To determine whether SARS-CoV-2 N suppressed IFNs, we … effect of SARS-CoV-2 N on
IFN signaling activities via IFN-β … the SARS-CoV-2 N protein to evade IFN-mediated response. …

… with primary immune responses to SARS-CoV infection and in … SARS-CoV infection
prompted coordinated innate immune responses that were dominated by antiviral IFN response …

… Using mice infected with SARS (severe acute respiratory syndrome)-CoV, we show that …
by delayed type I interferon (IFN-I) signaling orchestrates inflammatory responses and lung …

… This battle between the IFN response triggered upon SARS-CoV-2 infection, its magnitude
and timing, and the efficacy of its antiviral tools in dispute against the viral evasion strategies …

The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation.
Here, we utilized an integrative approach combining epidemiology, virus genome …

… SARS-CoV-2 hijacks the host ubiquitin system to enhance ORF7a’s ability to antagonize IFN-I
responses… Collectively, we show for the first time that SARS-CoV-2 ORF7a usurps the host …

… children and adults in their response to SARS-CoV-2 infection, we … in an interferon-activated
state, which after SARS-CoV-2 … higher paediatric innate interferon responses restrict viral …

… Bolstering the antiviral response with intranasal administration of recombinant IFN-I reduced
… the systemic host response to SARS-CoV-2 infection and supports use of intranasal IFN-I as …