… -β), II (IFN-γ), or III (IFN-λ1) IFN response in moDCs and MDMs. The attenuated host IFN
response is consistent with our previous findings from SARS-CoV-2–infected ex vivo human …

… cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activity. However,
this particular interferon response is interrupted by factors such as SARS-CoV-2 non-…

… point towards an important role for interferon signalling in combatting SARS-CoV-2. This
is underlined by studies that have found that neutralizing autoantibodies to interferon-α (IFNα) …

… the strategies of SARS-CoV-2 for evasion of innate immunity (particularly the antiviral IFN
responses), understanding of which will facilitate not only the elucidation of SARS-CoV-2 …

… the IFN response. Indeed, we show that the IFN response is efficiently blocked during
SARS-CoV-2 … Our study provides new insights on how SARS-CoV-2 evades the IFN response to …

… Interrogating the genetic factors and host-pathogen interactions that shape the host IFN
response during infection improves our understanding of the efficacy and therapeutic timing of …

… To determine the effect of blunting the type I interferon response on virus replication in
Calu-3 cells, we pretreated the cells for 2 h with 100 nM ruxolitinib (Invivogen, San Diego, CA, …

… profiling platform, we find the virus corresponds to distinct spatial expression of interferon
response genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection. …

… This was associated with a reduction of SARS-CoV-2 genome copy … support SARS-CoV-2
infection, replication, and de novo infectious virus production and that the type III IFN response …

… These observations might further highlight the need to apply IFN-I via intranasal route or
inhalation, as the IFN response in the periphery is already highly stimulated, and systemic …