… trial regimens should be carefully designed based on the temporal characteristics and
subtype specificity of IFN responses during SARS-CoV-2 infection and the disease progression […

… Taken together, an early deficient IFN response and the following hyper-inflammatory state
are the hallmarks of severe SARS-CoV-2 infection. The authors therefore suggested that IFN-…

… IFN response constitutes a major first line of defense against viruses. For many respiratory
viruses, including SARS-CoV-1, IFN … resistance and activating adaptive immune responses. …

… the host IFN response, further adding to the growing evidence that N can act as an IFN
antagonist … SARS-CoV-2 critical time to replicate and spread in an optimal cellular environment. …

… The reason for the dampened interferon response to SARS-CoV-2 is not known and is
currently being investigated. The signalling cascades in infected epithelial cells that lead to …

… genes is important for deeper understanding of SARS-CoV-2 tropism and pathogenesis. …
interleukin-13, and that the interferon response to respiratory viruses highly upregulates ACE2 …

… in response to IFN-α2b injection. Our findings in ferrets suggested IFN-α2b injection and
SARS-CoV … IFN responses were activated following SARS-CoV infection 2 days post-infection. …

… to, type I IFN, while stronger type I IFN responses have … SARS-CoV-2 encodes proteins to
antagonize IFN responses 7,8,9,10 , however supplementing the natural IFN response with IFN …

… to an impaired interferon response and abnormal inflammatory responses observed in
other zoonotic coronavirus infections, such as SARS -CoV and MERS-CoV [44]. SARS-CoV-2 …

… I interferon responses seen in severe SARS-CoV-2 infection, which in patients is marked by
decreased IFN-α, type I IFN … Our data suggest that the lack of type I IFN receptor signalling …