Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
… I interferon (IFN-I)-dependent induction of interferon-stimulated genes (ISGs). Together, we
find that SARS-CoV-2 shuts down host innate immune responses … against the IFN response. …
find that SARS-CoV-2 shuts down host innate immune responses … against the IFN response. …
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection
… Analysis of immune responses in patients with COVID-19 showed that SARS-CoV-2 … cells
4 and dampens antiviral type I and type III interferon responses 5 , in parallel to an excessive …
4 and dampens antiviral type I and type III interferon responses 5 , in parallel to an excessive …
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
… To assess both the cytokine and IFN response to SARS-CoV-2–infected AAV-hACE2
mice, we performed RNA sequencing from infected lung at 2 DPI. In contrast to the control-infected …
mice, we performed RNA sequencing from infected lung at 2 DPI. In contrast to the control-infected …
Coronaviral infection and interferon response: the virus-host arms race and COVID-19
… between SARS-CoV-2 proteins and human antiviral interferon sensors. We found that
SARS-CoV-2 actively interacts with PRR sensors and antiviral pathways by avoiding interferon …
SARS-CoV-2 actively interacts with PRR sensors and antiviral pathways by avoiding interferon …
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?
… However, patients with a persistent interferon response showed lower oxygen saturation …
SARS-CoV and poor clinical outcomes. This study suggests that persistent interferon responses …
SARS-CoV and poor clinical outcomes. This study suggests that persistent interferon responses …
Proteomic signature of host response to SARS-CoV-2 infection in the nasopharynx
PM Vanderboom, DG Mun, AK Madugundu… - Molecular & Cellular …, 2021 - ASBMB
… responses. Type III IFN (IFN-λ) signaling is less potent, slowly induced but more sustained
relative to the type I IFN response, which is more potent, rapidly induced, and transient ( …
relative to the type I IFN response, which is more potent, rapidly induced, and transient ( …
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
… To further characterize this late induction of the IFN response, we evaluated cytokine transcript
and viral RNA levels over a 72 h time course of infection. In Calu-3 cells, we observed an …
and viral RNA levels over a 72 h time course of infection. In Calu-3 cells, we observed an …
Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19
… Infection with SARS-CoV-1 is detected by various intercellular … Importantly, SARS proteins
can inhibit antiviral response by … of type 1 interferons and impaired antiviral response, while …
can inhibit antiviral response by … of type 1 interferons and impaired antiviral response, while …
SARS-CoV-2 infection: host response, immunity, and therapeutic targets
P Shivshankar, H Karmouty-Quintana, T Mills… - Inflammation, 2022 - Springer
… and by interfering with downstream IFN responses [61]. Recent study indicated that the Alpha
variant of SARS-CoV-2 suppresses innate immune responses more efficiently compared to …
variant of SARS-CoV-2 suppresses innate immune responses more efficiently compared to …
Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
A Sokal, P Bastard, P Chappert… - Journal of Experimental …, 2022 - rupress.org
… deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia.
We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive …
We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive …