… The effect of IL-1 blockade appears to be superior to that of steroids and result in prolonged
periods without flares. Although some studies report that urate crystals directly activate the …

… blockers that have been developed recently have provided opportunities to validate the
effect IL-1 blockade in preclinical models. The use of a recombinant chimeric protein composed …

… IL-1 blockade with anakinra has been shown to prevent adverse cardiac remodeling and
HF in animal models of acute myocardial infarction (AMI) and reduce the incidence of HF in …

… The current study demonstrates the beneficial effect of IL-1 blockade via the topical application
of IL-1Ra in treating the ocular signs and reversing the inflammatory changes associated …

Objective Anti–tumor necrosis factor α (anti‐TNFα) therapy has shown efficacy in the
treatment of rheumatoid arthritis (RA). Since interleukin‐1 (IL‐1), TNFα, and IL‐17 have many …

… features may benefit from interleukin-1 receptor blockade. … In this subgroup analysis,
interleukin-1 receptor blockade was … be undertaken to confirm the role of interleukin-1 blockage. …

… included in this meta-analysis ( Figure 1 and Supplementary Appendix 1). Overall, this meta-…
-1 blockade group and 732 in the control group. Among the patients receiving IL-1 blockade…

… interleukin-8 (IL-8) appears to be involved. We asked whether adherence of cells bearing a
membrane-form of interleukin 1 (IL-1) … Blockade of IL-1 receptors on PBMC did not affect the …

… The sustained reduction of CRP and IL-6 levels at 39 weeks after anakinra withdrawal is
notable and indicates that transient IL-1 blockade is capable of inducing not only a metabolic …

… (1). Tissue injury stimulates the formation of the inflammasome and the production of interleukin
(IL… and systemic inflammatory response, also known as the “fever molecule”(4)(Figure 1). …