… A growing number of monogenic autoinflammatory diseases are known to be caused by
dysregulation in cytokine pathways other than interleukin (IL)-1 (reviewed in 6, 7), but this …

… or danger signals, leading to IL-1 (interleukin-1) release and inflammatory response amplification.
… We hypothesize that IL-1 blockade with anakinra is feasible and can safely modulate …

… for IL 1 in septic shock requires specific IL 1 blockade. An IL 1 specific inhibitor … of LPSinduced
death (10), and the model used in the present study, selective blockade with the IL ira …

… evaluate the ability of interleukin 1 receptor antagonist (IL-1Ra) and recombinant human
TNF binding protein type 1 (rhTBP-1) to block IL-1-induced HIV-1 replication. We found that IL-…

… These data suggest that transient blockade of interleukin 1 receptors is … Interleukin 1 receptor
antagonist inhibits interleukin 1 induced cytokine synthesis and the binding of interleukin-1 …

In this review, 2 cytokines are discussed with respect to the inflammatory processes that are
fundamental to aging and mortality. Both interleukin (IL)-1 and IL-18 are members of the …

▪ Abstract The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that
binds to IL-1 receptors but does not induce any intracellular response. Two structural variants …

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

Background Increased systemic and tissue levels of interleukin (IL)-1β are associated with
greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis …

… have been observed in studies using IL-1 blockade as first-line therapy as compared to
studies in which IL-1 blockade was initiated later in the disease course (1–4). However, this is …