We have previously described the expression of interleukin cytokines (IL)-1α, IL-1β, and IL-1
receptor antagonist (IL-1ra) in human breast cancer (HBC) tissue. Based on our previous …

… Our focus in this review is to summarize the known data on the role of IL-1 in tumor
progression and metastasis and the use of IL-1 inhibition as a novel therapeutic approach in the …

… important in tumorigenesis and tumor progression, our IL-1 activated secretome study …
1-induced tumor secretome can modulate glioma and the tumor microenvironment including tumor …

… For example, IL-1β secreted by MDSCs and macrophages contribute to tumor progression
via their immunosuppressive effects in the tumor microenvironment. In contrast, IL-1β …

… In control immune intact mice, these immunogenic variants are eradicated during tumor
progression, and low- or non-immunogenic tumors appear in such carcinogen-treated mice, in a …

… By now, chronic inflammation is recognized as one of the hallmarks in carcinogenesis, tumor
progression, and metastasis [198,199]. Chronic inflammation results from the inability of the …

… Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important role in tumor
progression… targeting IL-1 should be considered in treating selected human tumors as well …

… As such, treatment of wild type mice with anti-IL-1β and anti-PD-1 was able to synergistically
inhibit tumor progression [95], suggesting that adjuvant IL-1 inhibition could improve BCa …

… of interleukin 1 (IL-1) influences tumor growth and metastases either through direct
proliferative effects or by promoting inflammatory and angiogenic pathways in host cells (1–4). IL-…

… Inflammation and immunity against the malignant cells represent hallmarks of the tumor …
process [1-10]. Usually, massive inflammation promotes tumor progression and concomitantly …