… Multiple innate signals regulate the genesis of effector and memory CD8 + T … interleukin
(IL)–12 and interferon (IFN)–α/β regulate distinct aspects of effector and memory human CD8 + T-…

Interleukin-12 (IL-12) induces differentiation of T helper 1 (Th1) cells, primarily through its
ability to prime T cells for high interferon-gamma (IFN-gamma) production. We now report that …

… In vivo, the adoptive transfer of IL13-zetakine + CD8 + CTL clones results in the regression
of established human glioblastoma orthotopic xenografts. Pilot clinical trials have been …

… CD8 + T cells differentiated into effector CD8 T cells that produced IFNγ and most were CD62L
lo . However, these DC-33 primed effector CD8 … and Listeria infections cells [13], [15] (Fig. …

… We have generated primary effector populations from naive CD8 T cells in response to
antigen and determined their patterns of cytokine secretion upon restimulation. The effect of …

… in the effector CD8 T cell … CD8 T cell response, a small subset of effector cells (∼5–15%)
had higher expression of IL-7Rα. This percentage tightly correlated with the number of effector …

… Besides the differential impact of signal 3 cytokines on the cell fate decision of effector CD8
T cells, we would like to emphasize the direct role of a signal 3 for survival of effector T cell in …

… interleukin-4 (IL-4) and IL-13 in protection against these parasites. These studies demonstrate
that while IL-4/IL-13 … (B) CD4 but not CD8 is required for expulsion of N. brasiliensis. BALB/…

… Here we explored the potential for signal 3 cytokines to recover effector functions of CD8
T cells directed against chronic viral infections. We found that upon IL-12 stimulation, HBV-…

… As IL-15 is critical for survival of most effector CD8 + T cells (7, 8), and effector CD4 + T
cells also increased CD122 expression, we next asked whether IL-15 contributed to …