Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin‐13 associated with increased skin fibrosis
P Fuschiotti, TA Medsger Jr… - Arthritis & Rheumatism …, 2009 - Wiley Online Library
… interleukin-13 (IL-13) were produced following activation of peripheral blood effector CD8+
T cells from SSc patients as compared with normal controls or with patients … IL-13 production. …
T cells from SSc patients as compared with normal controls or with patients … IL-13 production. …
Evaluation of interleukin 13 polymorphisms in systemic sclerosis
B Granel, C Chevillard, Y Allanore, V Arnaud… - Immunogenetics, 2006 - Springer
… In the total patient … IL13 polymorphisms, IL13 rs1800925 (IL13-1055), and IL13 rs2243204,
and disease (p=0.03–0.04). The IL13 rs2243204T allele was more common in SSc patients (p…
and disease (p=0.03–0.04). The IL13 rs2243204T allele was more common in SSc patients (p…
Role of interleukin‐13 in fibrosis, particularly systemic sclerosis
S O'Reilly - Biofactors, 2013 - Wiley Online Library
… levels are elevated both in the blood and in the skin of patients. This review will examine
the role of IL-13 in driving fibrosis with a particular emphasis on systemic sclerosis as a …
the role of IL-13 in driving fibrosis with a particular emphasis on systemic sclerosis as a …
Interleukin‐13–producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis
P Fuschiotti, AT Larregina, J Ho… - Arthritis & …, 2013 - Wiley Online Library
… interleukin-13 (IL-13) production by peripheral blood effector CD8+ T cells from SSc patients
… The present study was undertaken to investigate the role of IL-13 production by CD8+ T …
… The present study was undertaken to investigate the role of IL-13 production by CD8+ T …
Interleukin-4 and interleukin-13 as possible therapeutic targets in systemic sclerosis
G Gasparini, E Cozzani, A Parodi - Cytokine, 2020 - Elsevier
… Levels of IL-4, IL-13 and CXCL4 are higher in the serum of SSc patients compared to … IL-4
prevents skin sclerosis. In SSc, CD8+ T lymphocytes secrete IL-13 and mediate dermal fibrosis …
prevents skin sclerosis. In SSc, CD8+ T lymphocytes secrete IL-13 and mediate dermal fibrosis …
Interleukin-13 in systemic sclerosis: relationship to nailfold capillaroscopy abnormalities
V Riccieri, T Rinaldi, A Spadaro, R Scrivo… - Clinical …, 2003 - Springer
… to investigate whether interleukin-13 (IL-13) serum levels correlate to different nailfold
capillaroscopy (NC) findings in patients with systemic sclerosis (SSc). IL-13 serum levels were …
capillaroscopy (NC) findings in patients with systemic sclerosis (SSc). IL-13 serum levels were …
Transforming growth factor-β increases interleukin-13 synthesis via GATA-3 transcription factor in T-lymphocytes from patients with systemic sclerosis
J Baraut, D Farge, F Jean-Louis, I Masse… - Arthritis research & …, 2015 - Springer
… (TGF)-β and interleukin (IL)-13 play a crucial role in the pathogenesis of systemic sclerosis
(SSc), … TFG-β alters IL-13 production in T lymphocytes from patients with SSc from that seen in …
(SSc), … TFG-β alters IL-13 production in T lymphocytes from patients with SSc from that seen in …
Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung
A Hancock, L Armstrong, R Gama… - American journal of …, 1998 - atsjournals.org
… of 13 versus 2 of 8, P < 0.01). IL-13 protein was detectable in the BALF of 8 of 13 patients with
… AMs of four subjects with systemic sclerosis were cultured and IL-13 protein was increased …
… AMs of four subjects with systemic sclerosis were cultured and IL-13 protein was increased …
Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression
… in the genes encoding interleukin 4 (IL4), interleukin 13 (IL13), … previous observations in
patients with systemic sclerosis (SSc… We genotyped a cohort of 2488 patients with SSc and 2246 …
patients with systemic sclerosis (SSc… We genotyped a cohort of 2488 patients with SSc and 2246 …
GATA‐3 up‐regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin‐13 production
TA Medsger Jr, DE Ivanco, L Kardava… - Arthritis & …, 2011 - Wiley Online Library
… Despite the importance of interleukin-13 (IL-13) in systemic sclerosis (SSc) and other fibrotic
… of interleukin-13 (IL-13) by peripheral blood effector CD8+ T cells is present in patients with …
… of interleukin-13 (IL-13) by peripheral blood effector CD8+ T cells is present in patients with …
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