… jointly to fibroblasts. To address this issue, we used the fibroblast production of IL-6, MCP-1, …
17A and TGF-β induced synergic responses specifically for IL-6 and MCP-1, but not for IL-8 (…

… it has been shown that epidermis stains very strongly for IL-6 and also fibroblasts in the …
to IL-6 in fibroblasts. In vitro cultures of dermal fibroblast cultured with anti-IL-6 antibodies …

… macrophages in systemic sclerosis with lung involvement. Am J … sclerosis produce
increased amounts of interleukin 6, but not transforming growth factor b 1. J Rheumatol 1996;23:291–6…

… systemic sclerosis (SSc) skin fibroblasts and the effect of IL-6 trans-signalling on fibroblasts.
… mRNA measurement of IL-6 in cultured SSc and normal fibroblasts. Data are representative …

… Fibroblasts from patients with SSc are phenotypically unique. … IL-6 is a profibrogenic cytokine.
It has been shown to either increase or decrease fibroblast proliferation, increase fibroblast …

… dermal fibroblasts is a hallmark of systemic sclerosis (SSc), … factor-beta (TGFβ) and interleukin-6
(IL-6) are key candidate … IL-6 pathway blockade on the biology of SSc fibroblasts in vivo …

… collagen clinical aspects of interleukin 6. Immunol Today by normal fibroblasts appear to
be … dermal fibroblasts by recombinant human interleukin 6. J Invest Dermatol 1991;97:686–92. …

… Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal
fibroblasts by recombinant human interleukin 6. J Invest Dermatol 199 1: 97: 686-692. LeRoy …

… reported that fibroblasts derived from clinically affected skin areas of patients with systemic
sclerosis (SSc) have the ability to overproduce several cytokines and growth factors (ie, IL-6, …

… Enhanced interleukin 6 production by cultured fibroblasts from patients with systemic
sclerosis in response to platelet derived growth factor. J Rheumatol 1998;25:1534–9. …