… systemic IL-6-mediated events. This review will outline the central role of sIL-6R in the
coordination of IL-6 responses. Details relating to the mechanisms of sIL-6R production will be …

… sIL-6R and IL-6 in which we connected the COOH-terminus of the sIL-6R and the NH 2 -terminus
of IL-6 … called Hyper-IL-6, turned out to be a perfect mimic of IL-6 trans-signaling in vitro …

… Interleukin-6 (IL-6) production and … IL-6 and its soluble receptors sIL-6R and sgp130 in IBD
are from small cohorts and partly contradictory, we systematically evaluated IL-6, sIL-6R and …

… the ratio of interleukin 6 and soluble interleukin 6 receptor. … -6 and/or to restrict systemic
IL-6 signaling. The aim of this study was to experimentally determine IL-6·sIL-6R and IL-6·sIL-6R·…

… a 3D structure of IL-6; the NH 2 - and the COOH-termini and the 4 α-helices A–D are indicated.
b Interleukin 6 binds to gp130 via sites II and III and with the IL-6R via site I. Only the first …

… We determined IL-6 and sIL-6R levels in serum … IL-6 and sIL-6R levels were measured
by a sensitive enzyme-linked immunoassay (Endogen for IL-6 and Quantiquine, R&D for sIL-6R). …

… To study the characteristics of interleukin 6 (IL6), soluble form of interleukin 6 receptor (sILR)/IL6
complex in obese children and adolescents and its relationship with insulin resistance (…

… In order to study the presence and kinetics of sIL6R in various fluids we developed an … IL-6.
Since no influence was found of either IL-6 in the sIL-6R ELISA or of sIL-6R in the IL-6 ELISA …

… biologicał activity of soluble IL-6 receptor (sIL-6R) in vivo. B-78 melanoma cells were
stably transfected with cDNAs encoding human IL-6, murine sIL-6R and human leukaemia …

… interleukin-6 receptor (sIL-6R) has an agonistic role because the soluble complex (IL-6/sIL-6R)
can activate cells that do not express IL-6R … sIL-6R and sgp130, regulate the action of IL-6…