… The newly synthesized transcript is then rapidly stabilized by the p38 MAPK pathway, which
targets ARE in the IL-8 mRNA through an unknown mechanism that may involve proteins …

A potent leukocyte chemotactic and activating cytokine, interleukin‐8 (IL‐8), is produced by
numerous types of cells in response to inflammatory stimuli. Accumulating evidence indicate …

… has evolved from a neutrophil chemoattractant to a promising therapeutic target for a wide
… Kunkel showed robust induction of IL-8 mRNA by stimulating various types of cells in vitro, …

… Stabilization of IL-8 mRNA can contribute to enhanced IL-8 expression, eg, in viral infection
(Citation22). Our recent studies showed that the IL-8 mRNA contains an ARE which consists …

… Cancer-related inflammation may therefore be a valuable target for therapeutic intervention.
Interleukin-8 (IL-8) or CXCL8 is a pro-inflammatory ELR + CXC-chemokine, originally …

Publisher Summary This chapter focuses on interleukin-8 (IL-8), which exerts its biological
activity through two high-affinity glycosylated receptors: IL-8RA and IL-8RB (or I and II). These …

… A novel polypeptide leukocyte chemotactic factor, interleukin 8 (IL-81,’ exhibits in vitro … IL-8
mRNA expression in several types of cells, although the molecular mechanism of IL-8 gene …

… In this study, we describe superinduction of interleukin 8 (IL-8) mRNA, an important … -8
mRNA levels 30-fold in H292 cells. Tumour necrosis factor α (TNF-α), which induced IL-8 mRNA 3-…

… Conclusion: We identify IL-8 as a novel target of miR-203 for posttranscriptional
suppression. These findings may have relevance in diseases in which miR-203 and IL-…

… and in βENaC-transgenic mice that are predicted to target IL-8 mRNA. miR-17 was identified
as a miRNA that regulates IL-8 and its expression was decreased in adult CF bronchial …