… Genetic evidence also supports a role for COX-2, since mice null for COX-2 have an 86% …
that COX-2 contributes to the development of intestinal tumours and that inhibition of COX is …

… Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient
to … intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2…

… will develop numerous intestinal polyps by early adulthood that eventually progress into
intestinal cancers. We treated APC min+/− mice with celecoxib (a selective COX-2 inhibitor, ad …

… Using the murine model of colon cancer in the Min+ (multiple intestinal neoplasia) mouse, …
that either nonselective NSAIDs or selective COX-2 inhibitors are potent suppressors of colon …

… of intestinal polyposis in ApcD716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). …
polyposis in ApcD716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 1996;…

… Moreover, when intestinal epithelial cells are forced to express COX-2 constitutively, they
develop an altered phenotype including changes in their adhesion properties and a resistance …

… DuBois et al24 noted that untransformed rat intestinal epithelial cell, RIE-1, expresses
COX-2 only minimally under normal culture conditions. We also found that expression of rat …

… of COX 2 mRNA into functional protein. Selective blocking of the IGF receptor inhibits this
mediated COX-2 … The development of intestinal adenomas was more than six-fold reduced in …

… , that COX-2 may play a role in the genesis of colorectal cancer (20–22, 41). Here we
describe a link between inhibition of intestinal cancer growth and selective inhibition of the COX-…

… Cox-2 enzyme.12,25,26 Despite direct and indirect evidence indicating the importance of
Cox-2 during intestinal … species that naturally develops intestinal cancer with any frequency is …