… The process of epithelial cell renewal within the intestine appears to be entirely dependent
… intestinal stem or progenitor cells. An intestinal stem cell (ISC), similar to stem cells of the …

… ) intermingled with the Paneth cells are likely to be the true intestinal stem cells. Definitive
proof for either model has proven elusive due to the lack of specific markers for these cells …

… Progenitor cells retain the ability … cells with stem cell loss, or 2 stem cells and eventual clone
dominance. This stochastic extinction of stem cell lines with eventual dominance of one cell …

… and regeneration in the intestinal epithelium. We investigate how the niche protects and
instructs intestinal stem cells, which processes drive differentiation of mature cells and how …

… , regulation of cell division and differentiation. Our knowledge of intestinal stem cell function
is … We will therefore describe how intestinal stem cells were characterized in this model with …

… Consequent intestinal damage is an important constraint that might be reduced, if it were
possible to selectively and transiently suppress intestinal stem cell proliferation during therapy. …

… label-retaining cells, located on average at the +4 position just above the … cells, as putative
stem cells. Herein, we propose that both these cell types represent true intestinal stem cells …

… Paneth cells and non-epithelial cells. The identification of new intestinal stem cell markers
has greatly improved our understanding of stem cell biology during homeostasis and disease. …

… To investigate the role of fetal LGR5 + cells in the establishment of the adult intestinal
stem cell population, we performed lineage tracing on this population from embryonic day (E)16.5. …

… In this review, we summarize recent findings on the identity and location of intestinal stem
cells and provide a critical appraisal of how different components of the surrounding niche …