A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

J Kou, Y Zhang, F Zhou, C Sindermann… - Psychological …, 2022 - cambridge.org
… whether efficacy may be influenced by dose frequency or genotype.MethodsIn a randomized…
5 days) intranasal oxytocin (24 international units) effects and oxytocin receptor genotype-…

Anxiolytic effects of chronic intranasal oxytocin on neural responses to threat are dose-frequency dependent

J Kou, Y Zhang, F Zhou, Z Gao, S Yao… - Psychotherapy and …, 2022 - karger.com
dose frequency, and trait anxiety-specific effects, such that the low-frequency (intermittent)
chronic dosage … first evidence that low-dose frequency chronic intranasal OT has the potential …

[HTML][HTML] “Less is more”: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain

D Martins, K Brodmann, M Veronese… - Progress in …, 2022 - Elsevier
… We further link physiological changes with the density of the oxytocinintranasal oxytocin
as a valid approach to engage central targets. Finally, we demonstrate that intranasal oxytocin

A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research

E MacDonald, MR Dadds, JL Brennan… - …, 2011 - Elsevier
… The total frequency of side-effects in this study was similar to studies involving the short-…
attention to the impact of intranasal oxytocin when applied in higher-dosage longer-term, when …

Intranasal oxytocin for negative symptoms of schizophrenia: systematic review, meta-analysis, and dose-response meta-analysis of randomized controlled trials

M Sabe, N Zhao, A Crippa, GP Strauss… - International Journal of …, 2021 - academic.oup.com
frequency and compliance monitoring. We suggest that at least 1 more RCT with a high dose
of intranasal oxytocin … drawn about the effect of intranasal oxytocin on negative symptoms. …

Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives

DS Quintana, KT Smerud, OA Andreassen… - Therapeutic …, 2018 - Taylor & Francis
… and neural effects of single-dose intranasal administration (8 and 24 IU doses), intravenous
… on the effect produced and on dose and, possibly, dosing frequency. If specific brain regions …

[HTML][HTML] Effects of intranasal administration of oxytocin and vasopressin on social cognition and potential routes and mechanisms of action

S Yao, KM Kendrick - Pharmaceutics, 2022 - mdpi.com
… the importance of dose magnitude and frequency for influencing … functional effects of intranasal
oxytocin and vasopressin in … importance of dose magnitude and frequency for influencing …

Oxytocin and migraine headache

A Tzabazis, S Kori, J Mechanic, J Miller… - … : The Journal of …, 2017 - Wiley Online Library
… effects of one month of intranasal oxytocin dosing did show a … in both chronic and high
frequency episodic migraineurs. This … intranasal oxytocin on headache frequency we observed in …

[HTML][HTML] Effects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial

N Daniels, M Moerkerke, J Steyaert, A Bamps… - Molecular Autism, 2023 - Springer
… both the oxytocin and placebo … intranasal oxytocin. Notably, in the single-blind phase,
participants who were first allocated to intranasal placebo and later changed to intranasal oxytocin

Intranasal oxytocin, social cognition and neurodevelopmental disorders: a meta-analysis

B Keech, S Crowe, DR Hocking - Psychoneuroendocrinology, 2018 - Elsevier
… By considering the influence of diagnosis, age, dose of IN-OT, frequency of administration
and outcome measures on the results of these studies, the present study aimed to more …