Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice

R Liu, D Sun, X Xing, Q Chen, B Lu, B Meng, H Yuan… - …, 2024 - Elsevier
… Because of the advantage of intranasal delivery of oxytocin … effect of intranasal application
of oxytocin on neuropathic pain and … the effect of intranasal oxytocin on neuropathic pain and …

Intranasal oxytocin attenuates reactive and ongoing, chronic pain in a model of mild traumatic brain injury

AC Meidahl, A Eisenried, M Klukinov… - … Head and Face Pain, 2018 - Wiley Online Library
… is characterized by allodynia and resembles that found in other central neuropathic pain
patients.6 Headache is also a common post-TBI manifestation in humans and the symptoms …

Intranasal administration for pain: oxytocin and other polypeptides

VN Bharadwaj, AZ Tzabazis, M Klukinov, NA Manering… - Pharmaceutics, 2021 - mdpi.com
pain, but not in men [61]. Similarly, a recent study on the perception of wound pain showed
that intranasal oxytocin reduced wound pain in … nerve—and have shown that nasal oxytocin

Evaluating the efficacy of intranasal oxytocin on pain and function among individuals who experience chronic pain: a protocol for a multisite, placebo-controlled …

JA Rash, TS Campbell, L Cooper, D Flusk… - BMJ open, 2021 - bmjopen.bmj.com
… with primary neuropathic painpain arising as a direct consequence of a lesion or disease
affecting the central or peripheral nervous system46—will be eligible. Neuropathic pain will …

Ventrolateral orbital cortex oxytocin attenuates neuropathic pain through periaqueductal gray opioid receptor

M Taati, E Tamaddonfard - Pharmacological Reports, 2018 - Elsevier
Oxytocin plays an important role in supraspinal modulation of pain. In the present study, we
… (VLOC) microinjection of oxytocin on neuropathic pain after blockade of opioid receptors in …

Intranasal oxytocin administration is associated with enhanced endogenous pain inhibition and reduced negative mood states

BR Goodin, AJB Anderson, EL Freeman… - … journal of pain, 2015 - journals.lww.com
… of intranasal oxytocin was associated with pain sensitivity, endogenous pain inhibitory …
can also be taken up by the trigeminal nerve to various brainstem structures. Along this line, …

Oxytocin and pain perception: from animal models to human research

S Boll, ACA De Minas, A Raftogianni, SC Herpertz… - Neuroscience, 2018 - Elsevier
… of pain perception only. The intranasal administration of OT did not reduce ischemic pain
sensitivity, but resulted in enhanced pain inhibition on the masseter, but not the forearm in a …

Up‐regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy‐induced neuropathic pain

L Li, P Li, J Guo, Y Wu, Q Zeng, N Li… - British Journal of …, 2023 - Wiley Online Library
Upregulation of the oxytocin receptors on peripheral sensory neurons mediated analgesia
in chemotherapy‐induced neuropathic pa Page 1 This article has been accepted for …

[HTML][HTML] An investigation on the role of oxytocin in chronic neuropathic pain in a Wistar rat model

M de Kock, S Chetty, AS Isa, L Qulu-Appiah - Neurobiology of Pain, 2024 - Elsevier
… Animals that received Paclitaxel and treated with oxytocin also … the hypothesis that intranasally
administered oxytocin may … on chronic pain management using intranasal oxytocin (Wang…

The effect of intranasal oxytocin administration on acute cold pressor pain: a placebo-controlled, double-blind, within-participants crossover investigation

JA Rash, TS Campbell - Psychosomatic medicine, 2014 - journals.lww.com
… treatment literature ( 2 ), despite adverse effects ( 3–5 ) and limited effectiveness in areas
such as neuropathic pain. There is a need for analgesics that are safe, have low adverse …