Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives

DS Quintana, KT Smerud, OA Andreassen… - Therapeutic …, 2018 - Taylor & Francis
… Some clinical trials have demonstrated effects on social … (ASD), 6 weeks of intranasal oxytocin
treatment was found to improve … -dependent effects of intranasal and intravenous oxytocin

A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

J Kou, Y Zhang, F Zhou, C Sindermann… - Psychological …, 2022 - cambridge.org
… 5 days) intranasal oxytocin (24 international units) effects and oxytocin receptor genotype-mediated
treatment … We also investigated similar effects on resting-state functional connectivity …

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
… [103] administered 6, 12, and 24 IU to healthy women and observed an increase in
amygdala reactivity across doses indicating that sex-specific treatment effects are not only a …

Intranasal oxytocin as a potential therapeutic strategy in post-traumatic stress disorder: A systematic review

G Giovanna, S Damiani, L Fusar-Poli… - …, 2020 - Elsevier
… In this systematic review, the potential effects of intranasal OT (INOT) administration on core
… showed a drug effect on reducing anhedonia in the PTSD group. No drug effect on reaction …

Are we there yet? The clinical potential of intranasal oxytocin in psychiatry

J CJ Liu, RA McErlean… - Current Psychiatry Reviews, 2012 - ingentaconnect.com
… In another study, Salzberg and Swedo compared the effects of intranasal oxytocin and saline
in three patients with OCD [78]. This time, they found no treatment effect on either clinician- …

A review of the safety, efficacy and mechanisms of delivery of nasal oxytocin in children: therapeutic potential for autism and Prader-Willi syndrome, and …

MM DeMayo, YJC Song, IB Hickie, AJ Guastella - Pediatric Drugs, 2017 - Springer
therapeutic potential of intranasal oxytocin in pediatric populations. Unique considerations
for dosing and delivery of oxytocin to the nasalIntranasal oxytocin has been administered to …

Intranasal oxytocin effects on social cognition: a critique

SL Evans, O Dal Monte, P Noble, BB Averbeck - Brain research, 2014 - Elsevier
… using intranasal OT are discussed. We then provide an overview of intranasal OT effects on
… with specifically “pro-social” effects. We incorporate findings published since other recent …

Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial

E Anagnostou, L Soorya, W Chaplin, J Bartz… - Molecular autism, 2012 - Springer
… studies suggest that the oxytocin system may be a potential therapeutic target for social …
to examine the safety/therapeutic effects of intranasal oxytocin versus placebo in adults with …

Intranasal oxytocin in the treatment of autism spectrum disorders: a review of literature and early safety and efficacy data in youth

E Anagnostou, L Soorya, J Brian, A Dupuis, D Mankad… - Brain research, 2014 - Elsevier
… Over 12 weeks of treatment, several measures of social … of effect 3 months past discontinuation
of intranasal oxytocin. … behavior rating scale for the assessment of treatment effects

The effects of intranasal oxytocin on the efficacy of psychotherapy for major depressive disorder: a pilot randomized controlled trial

MA Ellenbogen, C Cardoso, L Serravalle… - Psychological …, 2024 - cambridge.org
… and many experience residual symptoms post-treatment. In this double-… nasal oxytocin
(OT) augments the therapeutic efficacy of psychotherapy for MDD and improves the therapeutic