Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management

VP Chavda, LK Vora, AK Pandya, VB Patravale - Drug discovery today, 2021 - Elsevier
… In this review, we provide an overview of nasal vaccines with a focus on formulation …
Here, we provide examples of intranasal vaccines that are being developed against SARS-CoV-2, …

Oral and intranasal vaccines against SARSCoV‐2: Current progress, prospects, advantages, and challenges

S Kar, P Devnath, TB Emran, TE Tallei… - Immunity …, 2022 - Wiley Online Library
… In this article, the current approaches used to develop effective oral and nasal mucosal
vaccines against SARSCoV‐2 and their benefits, prospects, and challenges have been …

[HTML][HTML] An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

AO Hassan, S Shrihari, MJ Gorman, B Ying, D Yuan… - Cell reports, 2021 - cell.com
… We recently reported the protective activity of an intranasallyintranasal immunization with
ChAd-SARS-CoV-2-S provides durable protection against historical and emerging SARS-CoV-…

Nasal vaccination against SARS-CoV-2: Synergistic or alternative to intramuscular vaccines?

M Tiboni, L Casettari, L Illum - International journal of pharmaceutics, 2021 - Elsevier
… So far, all the approved vaccines are by intramuscular (IM) injection only, although different
… on development of an intranasal (IN) SARS-CoV-2 vaccine. Ideally a vaccine, at least against …

[HTML][HTML] Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

MW Ku, M Bourgine, P Authié, J Lopez, K Nemirov… - Cell host & …, 2021 - cell.com
… hamsters, which are naturally permissive to SARS-CoV-2 replication and closely mirror …
of LV-based vaccination against SARS-CoV-2 and designate intranasal immunization as a …

Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2

X An, M Martinez-Paniagua, A Rezvan, SR Sefat… - Iscience, 2021 - cell.com
… 2 virus breaches before dissemination to the lung. We report the development of an intranasal
subunit vaccine … This vaccine induces systemic neutralizing antibodies, IgA in the lung and …

Intranasal immunization with inactivated SARS-CoV (SARS-associated coronavirus) induced local and serum antibodies in mice

D Qu, B Zheng, X Yao, Y Guan, ZH Yuan, NS Zhong… - Vaccine, 2005 - Elsevier
vaccines to develop antibody enhancement phenomenon. Herein, we report the experimental
immunization of mice by inactivated SARS-CoV … in serum in intranasally immunized mice. …

An intranasal vaccine based on outer membrane vesicles against SARS-CoV-2

HB Thapa, AM Müller, A Camilli, S Schild - Frontiers in Microbiology, 2021 - frontiersin.org
vaccine-platforms, which are safe, effective, and can be modified to carry antigens of emerging
pathogens. The current SARS-CoV-2 vaccines … a novel SARS-CoV-2 vaccine candidate …

Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection

JL Americo, CA Cotter, PL Earl… - Proceedings of the …, 2022 - National Acad Sciences
… While intramuscular vaccination prevented morbidity and cleared SARS-CoV-2 from the …
after challenge, intranasal vaccination was more effective as neither infectious virus nor viral …

Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

G Baldeon Vaca, M Meyer, A Cadete, CJ Hsiao… - Science …, 2023 - science.org
… At 3 days after SARS-CoV-2 challenge, intranasally vaccinated hamsters had lower viral …
indicate that intranasal vaccination with an mRNA-LNP SARS-CoV-2 vaccine is protective and …