Intratumoral heterogeneity and clonal evolution induced by HPV integration
… of aberrant host DNA replication and recombination induced by HPV integration. We
conclude that HPV integration promotes intratumoral heterogeneity and clonal evolution. …
conclude that HPV integration promotes intratumoral heterogeneity and clonal evolution. …
[HTML][HTML] Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancer
… + OPSCC (Supplementary Table 1), this review focuses on tumor heterogeneity in primary
HPV + … These may affect the determination of HPV integration in tumor samples, as a small …
HPV + … These may affect the determination of HPV integration in tumor samples, as a small …
Multi-region sequencing depicts intratumor heterogeneity and clonal evolution in cervical cancer
C Wang, R Bai, Y Liu, K Wang, Y Wang, J Yang, H Cai… - Medical Oncology, 2023 - Springer
… , the correlation between genetic heterogeneity and HPV integration in cervical … HPV
integration analysis to explore intratumor heterogeneity in cervical cancer. We sequenced 20 tumor …
integration analysis to explore intratumor heterogeneity in cervical cancer. We sequenced 20 tumor …
Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine
H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
… strains of human papillomavirus (HPV), primarily HPV-16, … peculiarities contribute to
intratumoral heterogeneity, therapy … may help integrate the microenvironment-tumor cell interplay …
intratumoral heterogeneity, therapy … may help integrate the microenvironment-tumor cell interplay …
[HTML][HTML] Cervical cancer heterogeneity: a constant battle against viruses and drugs
Q Sun, L Wang, C Zhang, Z Hong, Z Han - Biomarker Research, 2022 - Springer
… environment to summarize the conditions of immune clearance and gene integration after
different HPV infections and to explore the genomic factors of tumor heterogeneity. Finally, we …
different HPV infections and to explore the genomic factors of tumor heterogeneity. Finally, we …
[HTML][HTML] Viral-cellular DNA junctions as molecular markers for assessing intra-tumor heterogeneity in cervical cancer and for the detection of circulating tumor DNA
K Carow, M Gölitz, M Wolf, N Häfner, L Jansen… - International journal of …, 2017 - mdpi.com
… Our study provides evidence that HPV-DNA integration is … -tumor homogeneity implies that
the tumor-specific integrate(s) were detected in all micro-dissected areas taken within a tumor …
the tumor-specific integrate(s) were detected in all micro-dissected areas taken within a tumor …
HPV integration in HNSCC correlates with survival outcomes, immune response signatures, and candidate drivers
… any common driver mechanism related to HPV integration (16). We have analyzed HPV
integration sites in the human transcriptome in 84 primary HPV + HNSC neoplasms collected at …
integration sites in the human transcriptome in 84 primary HPV + HNSC neoplasms collected at …
Tumor evolution and intratumor heterogeneity of an oropharyngeal squamous cell carcinoma revealed by whole-genome sequencing
XC Zhang, C Xu, RM Mitchell, B Zhang, D Zhao, Y Li… - Neoplasia, 2013 - Elsevier
… intratumor genetic heterogeneity within a single tumor, we performed whole-genome sequencing
on three separate regions of an human papillomavirus (HPV)-… HPV genome integration …
on three separate regions of an human papillomavirus (HPV)-… HPV genome integration …
[HTML][HTML] Molecular tumor subtypes of HPV-positive head and neck cancers: biological characteristics and implications for clinical outcomes
… and their relationship with clinical characteristics and HPV integration into the host genome.
… However, the subgroups still show heterogeneous HPV integration status: out of the 66 HPV…
… However, the subgroups still show heterogeneous HPV integration status: out of the 66 HPV…
[HTML][HTML] HPV18 E6 and E7 Intratumour Heterogeneity in Esophageal Cancer
S Khodahemmati, M Gaffar, J Li, Y Wang… - Journal of Cancer …, 2019 - scirp.org
… We investigated the intra-tumor heterogeneity of HPV E6 and E7 in esophageal cancer and
… in HPV DNA integration needed to explore the mains specific integration site of HPV DNA in …
… in HPV DNA integration needed to explore the mains specific integration site of HPV DNA in …
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