Chemistry and pharmacokinetics of gallium maltolate, a compound with high oral gallium bioavailability

LR Bernstein, T Tanner, C Godfrey… - Metal‐Based Drugs, 2000 - Wiley Online Library
… results on oral gallium maltolate, data on intravenously administered gallium were obtained
… justified without further information on gallium distribution and metabolism that support the …

Gallium-68: a systematic review of its nononcological applications

M Vorster, A Maes, C Van deWiele… - Nuclear Medicine …, 2013 - journals.lww.com
… a more accurate picture of ventilation distribution in the setting of … tool for the assessment of
ventilation distribution’ 19 . … evaluated the uptake of intravenously administered 68 Ga-DOTA-…

Mechanisms of localization of gallium-67 in tumors

SM Larson - Seminars in nuclear medicine, 1978 - Elsevier
… After intravenous administration, ~TGa is bound to transferrin in the blood, and distributed
to liver, lacrimal glands, salivary … Within the cells of the liver and tumors, gallium is found in …

Mechanisms of therapeutic activity for gallium

LR Bernstein - Pharmacological reviews, 1998 - ASPET
… entirely consistent, all Ga tissue distribution studies find that Ga concentrates at the same …
for nephrotoxicity when Ga is administered other than by high-dose rapid intravenous bolus. …

Intra-tracheal administration increases gallium availability in lung: implications for antibacterial chemotherapy

E Mitidieri, D Visaggio, E Frangipani, C Turnaturi… - Pharmacological …, 2021 - Elsevier
… vs iv administered Ga(III), in terms of bio-distribution and lung … the use of Ga(III) for inhalation
since intra-tracheal Ga(III) … of citrate-buffered gallium nitrate (GaN) by intravenous (iv) route …

Gallium in cancer treatment

MA Jakupec, BK Keppler - Current Topics in Medicinal …, 2004 - ingentaconnect.com
… This is supported by studies on the tissue distribution and tumor uptake of gallium in rats …
of gallium from blood to tumor cellsis not altered compared to its intravenous administration as a …

[PDF][PDF] Preclinical toxicology and tissue gallium distribution of a novel antitumour gallium compound: tris (8-quinolinolato) gallium (III).

P Collery, JL Domingo, BK Keppler - cancer, 1996 - researchgate.net
administration of Ga nitrate has been proposed to treat malignant diseases (5). After the
intravenous administration of Ga nitrate, Ga … (21), with the Ga doses being limited by renal toxicity…

Gallium in cancer treatment

P Collery, B Keppler, C Madoulet, B Desoize - Critical reviews in oncology …, 2002 - Elsevier
… A modification of cell cycle distribution is observed after at least 24 h incubation with Ga: the
… The drug is administered intravenously, either as a bolus every 3 weeks or as continuous …

Gallium: New developments and applications in radiopharmaceutics

PJ Blower, R Cusnir, A Darwesh, NJ Long… - Advances in Inorganic …, 2021 - Elsevier
Ga-Galmydar has a uniform distribution of delocalized … fraction of ionic gallium administered
intravenously reaches the … delivery of gallium to tumors after administration of 67/68 Ga-…

Medical applications and toxicities of gallium compounds

CR Chitambar - International journal of environmental research and …, 2010 - mdpi.com
… Presently, gallium nitrate needs to be given to patients by continuous intravenous administration
… This article is an open-access article distributed under the terms and conditions of the …