… mechanisms inherent in EGFR or by EGFR-independent … intrinsic EGFR-TKI-resistance and
differences and similarities with acquired resistance and among clinically implemented EGFR…

… resistance. Citation3,Citation4 This review focuses on the recently identified molecular
mechanisms of intrinsic resistance to EGFR … therapeutic strategies to overcome this resistance. …

… Here we review and summarize the known resistant mechanisms to EGFR-TKIs and provide
… Although the polymorphism was sufficient to confer intrinsic TKI resistance in chronic …

… EGFR signaling, EGFR blocking monoclonal antibodies and small molecular weight EGFR
tyrosine … -regulated proliferation and an intrinsic resistance to anticancer drugs. Furthermore, …

… associated with the mutation, suggesting the possibility of intrinsic resistance in these
patients. Initially, steric hindrance of TKIs by the “gatekeeper” T790M mutation has been …

AKT and MAPK signaling are involved in the resistance of breast cancer cells to the EGFR
tyrosine kinase inhibitor gefitinib. RAS proteins are upstream mediators that transfer …

… signaling through EGFR-independent receptor tyrosine kinases functions as a mechanism
of intrinsic resistance to EGFR TKIs in NSCLC not bearing EGFR or K-Ras mutations. …

… upon resistance mutations, we performed EGFR (epidermal-growth-factor receptor) resistance
… with T790M in the same EGFR allele conferred complete resistance to erlotinib, lapatinib …

… factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) in … Intrinsic resistance may
also be the consequence of … of patients with sensitising EGFR mutations to EGFR-TKIs treatment…

… High-level HGF expression, EGFR T790M … resistance, respectively. High-level HGF expression
was detected in 29% of tumors with intrinsic resistance (nonresponders), whereas EGFR …