The capsaicin receptor: a heat-activated ion channel in the pain pathway
MJ Caterina, MA Schumacher, M Tominaga, TA Rosen… - Nature, 1997 - nature.com
… This receptor is a non-selective cation channel that is structurally related to members of the
TRP family of ion channels. The cloned capsaicin receptor is also activated by increases in …
TRP family of ion channels. The cloned capsaicin receptor is also activated by increases in …
Capsaicin receptor in the pain pathway
M Tominaga, D Julius - The Japanese Journal of Pharmacology, 2000 - jstage.jst.go.jp
… for many ion channels, including cyclic nucleotide-gated channels … similarity with most of
these channels, it is slightly more … TRP (transient receptor potential) family of ion channels (see …
these channels, it is slightly more … TRP (transient receptor potential) family of ion channels (see …
Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel
… of capsaicin and its receptor the transient receptor potential vanilloid type 1 ion channel (…
an account of our current knowledge of the pharmacology of the capsaicin receptor, TRPV1. …
an account of our current knowledge of the pharmacology of the capsaicin receptor, TRPV1. …
Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel
J Jung, SW Hwang, J Kwak, SY Lee… - Journal of …, 1999 - Soc Neuroscience
… Recently, an acid-sensitive channel was cloned in DRG neurons (Waldmann et al., 1997)…
ion channel, the acid-sensitive ion channel is permeable to cations. The acid-sensitive channel …
ion channel, the acid-sensitive ion channel is permeable to cations. The acid-sensitive channel …
Capsaicin receptor VR1 and ATP‐gated ion channel P2X3 in human urinary bladder
Y Yiangou, P Facer, A Ford, C Brady… - BJU …, 2001 - Wiley Online Library
… Capsaicin receptor VR1 and ATP-gated ion channel P2X 3 … capsaicin sensitivity of sensory
neurones [28]. The present study also confirmed the presence of the ATP-gated ion channel …
neurones [28]. The present study also confirmed the presence of the ATP-gated ion channel …
Binding of capsaicin to the TRPV1 ion channel
L Darré, C Domene - Molecular pharmaceutics, 2015 - ACS Publications
… Transient receptor potential (TRP) ion channels constitute a notable family of cation channels
… One of the most experimentally studied agonist of TRP channels is capsaicin, which is …
… One of the most experimentally studied agonist of TRP channels is capsaicin, which is …
Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel
… To reveal the molecular interactions between capsaicin and the channel, we decomposed
the calculated binding energy and examined the spatial distribution of each energy …
the calculated binding energy and examined the spatial distribution of each energy …
A capsaicin-receptor homologue with a high threshold for noxious heat
MJ Caterina, TA Rosen, M Tominaga, AJ Brake… - Nature, 1999 - nature.com
… By analogy, our findings indicate that related ion channels may account for thermal
responsiveness over a range of noxious temperatures. In addition to its abilityto sense noxious heat, …
responsiveness over a range of noxious temperatures. In addition to its abilityto sense noxious heat, …
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and …
A Leffler, B Mönter, M Koltzenburg - Neuroscience, 2006 - Elsevier
… the capsaicin receptor and acid-sensing ion channels suggest … capsaicin receptor TRPV1
and acid-sensing ion channels (… showed that the majority of capsaicin-sensitive rat dorsal root …
and acid-sensing ion channels (… showed that the majority of capsaicin-sensitive rat dorsal root …
Acid potentiation of the capsaicin receptor determined by a key extracellular site
SE Jordt, M Tominaga, D Julius - Proceedings of the …, 2000 - National Acad Sciences
… receptors are nociceptor-specific cation channels that serve as the molecular target for
capsaicin… VR1 is homologous to members of the transient receptor potential family of ion channels …
capsaicin… VR1 is homologous to members of the transient receptor potential family of ion channels …
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