… , are involved in the growth/proliferation, migration and/or invasion of cancer cells. In this …
ion channels in the development of cancer. Keywords: Ion channels, cancer, therapeutic targets…

… , the field exploring ion channel function in relation to cancer has … the impact of ion channel
modulators on cancer growth have … targeting diverse ion channels in various cancer models …

… variety of channel types are involved in cancer … ion channels impairs the growth of cancer
cells. Recently, these studies have been followed up in vivo, hence revealing that ion channels …

… that ion channel blockers, especially for K + and Cl − channels, … of ion channels in the
biology of cancer cells [1,2]. Prominent alterations in the expression and activity of ion channels …

… These few examples show that ion channels are already used as therapeutic targets and
the principal limitations of ion channels in cancer therapy may not be higher than for any other …

… selective for Cl − , Ca 2+ , and nonselective cation channels. This short review summarizes
the current knowledge of the role of these ion channels in proliferation and cancer …

… to intrinsic apoptosis, modulation of their ion channels leading to cytochrome c release may
… the known mitochondrial ion channels and of their modulators capable of killing cancer cells. …

… Ion channels play critical roles in cancer pathophysiology by several mechanisms. Ion
channels like Ca 2 + , and Na + /K + control cancer … A cancer cell undergoes changes in the cell …

… Tumour-relevant ion channels are upregulated by growth factors and hormones [10] to the …
a given ion channel is critically important for the survival of a tumour cell, this ion channel may …

… Considerable advances have also been made in anti-angiogenesis therapy, because …
indicating that ion channels should be included among the novel targets for cancer therapy, …