… on the course of cancer progression. Here, we summarize recent knowledge of tumour
metabolism and the tumour microenvironment, placing it in the context of tumour pH regulation, …

… how ion channels, transporters, and cellular sensors under influence of the acidic tumor
microenvironment shape cancer development and progression and affect the potential of cancer …

… relating to elevated Na + in the tumour microenvironment and how this may be regulated
by several classes of Na + channels and transporters. In particular, our understanding of how …

… membrane powers the transport of H + ions and essential nutrients … “ionic tumour
microenvironment” can determine how cancer, … of ion homeostasis within the tumour …

… cells must be reconsidered, and cancer must be viewed as a “… microenvironment, that tumor
cells construct and remodel during multistep tumorigenesis. The “tumor microenvironment” (…

… other transport proteins important for cancer progression, such … of solid tumors and their
interrelationship with key ion transport … transport proteins with known or proposed roles in cancer …

… In this article, we highlight the importance of tumor microenvironment in mediating the … -associated
transmembrane enzyme, involving in pH regulation and ion transportCitation89. The …

… To test whether the gain of function observed as a result of Kcna3 overexpression
resulted from increased ion transport, we generated a non-conducting ‘pore dead’ construct (…

… In the present review, we focus on one such ion transporter, the … four other ion transporters,
voltage-gated sodium channels, V-ATPases, anion exchangers and bicarbonate transporters. …

… Other ion exchangers and bicarbonate transporters are important in pHi maintenance, but
… or destroy resistant breast cancer cells in the tumour microenvironment, and could prove a …