… with iron, but the net effect has not been clarified. Conclusions. In haemochromatosis, iron
absorption is … Dietary modifications that lower iron intake and decrease iron bioavailability may …

… Major questions also remain unanswered about the role of HFE, and other genes mutated
in haemochromatosis, in iron absorption and maintenance of homoeostasis of iron. The …

… definition excludes rare genetic disorders that lead to systemic iron excess by …
haemochromatosis in individuals homozygous for C282Y by decreasing iron absorption or …

… haemochromatosis, increased iron absorption leads to dramatic expansion of the iron
stores while iron … becomes starved of iron leading to activation of the genetic iron import-export …

… iron absorption, a proportion of haemochromatosis patients have wildtype HFE but have
mutations in other genes… , characterized by deregulation of iron absorption, may provide insights …

… of 30 years, is inherited in an autosomal recessive fashion and is characterised by excessive
iron absorption from the GI tract, excessive iron release from RES macrophages, excessive …

… Increased iron absorption leads to a positive iron balance and accumulation of excess body
iron in genetic haemochromatosis. It is interesting that only specific organs are affected by …

… in our understanding of key regulatory mechanisms of iron homeostasis. … called
haemochromatosis type 1, which is characterized by increased duodenal iron absorption and rapid …

… genes associated with iron homeostasis will enhance our diagnostic certainty of primary
haemochromatosis … negative feedback of iron absorption in the gut is defective, iron continues to …

… the haemochromatosis gene identified in population screening studies, who have been followed
up for many years, do not develop iron … A diagnosis of haemochromatosis based on iron …